ArticleJournal of biomedical materials research. Part A2021
Potential damage in pulmonary arterial hypertension: An experimental study of pressure-induced damage of pulmonary artery.
Article in Journal of biomedical materials research. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Baseline state for pulmonary vasculature with pulmonary arterial hypertension: effect of geometric remodeling and metabolic shift.Biomechanics and modeling in mechanobiology · 2026Article
- Tissue compliance characterization for human umbilical arteries after decellularization.Journal of the mechanical behavior of biomedical materials · 2026Article
- Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.Device · 2026Article
- Constitutive neural networks for main pulmonary arteries: discovering the undiscovered.Biomechanics and modeling in mechanobiology · 2025Article
- The effects of bolus isosorbide dinitrate on pulmonary hypertension with cardiopulmonary comorbidities.Heart and vessels · 2025Article
- Understanding Pulmonary Autograft Remodeling After the Ross Procedure: Stick to the Facts.Frontiers in cardiovascular medicine · 2022Review
- Plasticity and Enzymatic Degradation Coupled With Volumetric Growth in Pulmonary Hypertension Progression.Journal of biomechanical engineering · 2021Article
- Inverse modeling framework for characterizing patient-specific microstructural changes in the pulmonary arteries.Journal of the mechanical behavior of biomedical materials · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pulmonary arterial hypertension (PAH) is associated with elevated pulmonary arterial pressure. PAH prognosis remains poor with a 15% mortality rate within 1 year, even with modern clinical management. Previous clinical studies proposed wall shear stress (WSS) to be an important hemodynamic factor affecting cell mechanotransduction, growth and remodeling, and disease progress in PAH. However, WSS in vivo is typically at most 2.5 Pa and a doubt has been cast whether WSS alone can drive disease progress. Furthermore, our current understanding of PAH pathology largely comes from small animals' studies in which caliber enlargement, a hallmark of PAH in humans, is rarely reported. Therefore, a large-animal experiment on pulmonary arteries (PAs) is needed to validate whether increased pressure can induce enlargement of PAs caliber. In this study, we use an inflation testing device to characterize the mechanical behavior, both nonlinear elastic behavior and irreversible damage of porcine arteries. The parameters of elastic behavior are estimated from the inflation test at a low-pressure range before and after over-pressurization. Then, histological images are qualitatively examined for medial and adventitial layers. This study sheds light on the relevance of pressure-induced damage mechanism in human PAH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.