ArticleAmerican journal of physiology. Heart and circulatory physiology2020
Development of an endothelial cell-restricted transgenic reporter rat: a resource for physiological studies of vascular biology.
Mikhail Alexeyev, Aron M Geurts, Naga S Annamdevula, C Michael Francis, Silas Josiah Leavesley, Thomas C Rich, Mark S Taylor, Mike T Lin, Ron Balczon, Jennifer Michelle Knighten and 2 more
Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
Pneumonia initiates a tauopathy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 3 institutions in 1 country.
Mikhail AlexeyevDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Aron M GeurtsGenome Editing Rat Resource Center, Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Naga S AnnamdevulaDepartment of Pharmacology, University of South Alabama, Mobile, Alabama.ORCID 0000-0003-3219-413X
C Michael FrancisDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Silas Josiah LeavesleyDepartment of Chemical and Biomolecular Engineering, University of South Alabama, Mobile, Alabama.ORCID 0000-0002-2684-9534
Thomas C RichDepartment of Pharmacology, University of South Alabama, Mobile, Alabama.
Mark S TaylorDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Mike T LinDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Ron BalczonDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama.
Jennifer Michelle KnightenDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Diego F AlvarezDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Sam Houston State University, Conroe, Texas.
Troy StevensDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
University of South Alabama · USMedical College of Wisconsin · USSam Houston State University · US
Funding
T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2001 to 2022
$34.6M
Nosocomial pneumonias impair cognitive functionR01HL140182 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Mike Lin · 2018 to 2026
$4.9M
Store-operated calcium entry: lung endothelial permeabilityR37HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2010 to 2019
$3.9M
Store Operated Calcium Entry: Lung Endothelial PermeabilityR01HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 1998 to 2009
$3.0M
Caspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0M
Lung Endothelial Aß in infectious proteinopathyR01HL148069 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2020 to 2023
$1.5M
TRPC4-mediated calcium signals accelerate vascular remodeling in pulmonary arterial hypertensionK25HL136869 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI FRANCIS, CHRISTOPHER MICHAEL · 2017 to 2021
Here, we report the generation of a Cre-recombinase (iCre) transgenic rat, where iCre is driven using a vascular endothelial-cadherin (CDH5) promoter. The CDH5 promoter was cloned from rat pulmonary microvascular endothelial cells and demonstrated ~60% similarity to the murine counterpart. The cloned rat promoter was 2,508 bp, it extended 79 bp beyond the transcription start site, and it was 22,923 bp upstream of the translation start site. The novel promoter was cloned upstream of codon-optimized iCre and subcloned into a
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Development of an endothelial cell-restricted transgenic reporter rat: a resource for physiological studies of vascular biology. · full record | OpenQuestion