Evidence map›Paper›PMID 32589399›Full record

ArticleACS chemical biology2020

Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy.

Kelly E Bird, Christian Xander, Sebastian Murcia, Alan A Schmalstig, Xianxi Wang, Michael J Emanuele, Miriam Braunstein, Albert A Bowers

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Thiostrepton as a Potential Therapeutic Agent for Hepatocellular Carcinoma.International journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kelly E BirdDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Christian XanderDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Sebastian MurciaDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Alan A SchmalstigDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Xianxi WangDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Michael J EmanueleDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Miriam BraunsteinDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Albert A BowersDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0001-8214-7484
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
MIRA Equipment SupplementR35GM125005 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Albert A Bowers · 2017 to 2026
$3.9M
Dual mechanism thiopeptide analogs for TB drug developmentR21AI138058 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOWERS, ALBERT A, BRAUNSTEIN, MIRIAM S. · 2018 to 2019
$413k
NCI NIH HHS P30 CA016086NIAID NIH HHS R21 AI138058NIGMS NIH HHS R35 GM125005
6 · The paper itself

Abstract

Thiopeptide antibiotics are emerging clinical candidates that exhibit potent antibacterial activity against a variety of intracellular pathogens, including

Indexed as

AnimalsAnti-Bacterial AgentsEukaryotic Initiation Factor-2Forkhead Box Protein M1MiceMitophagyMycobacterium tuberculosisPeptidesPhosphorylationProteasome Endopeptidase ComplexRAW 264.7 CellsSulfhydryl CompoundsAnti-Bacterial AgentsEukaryotic Initiation Factor-2Forkhead Box Protein M1Foxm1 protein, mousePeptidesProteasome Endopeptidase ComplexSulfhydryl Compounds

Identifiers

PMID32589399
PMCPMC7442609
OpenAlexW3037868802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.