ArticleEpilepsia2020
Interictal intracranial electroencephalography for predicting surgical success: The importance of space and time.
Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- AI-Driven Mapping of Seizure Spread Patterns.Annals of neurology · 2026Article
- Virtual Responsive Neurostimulation Implantation: From Intracranial Connectivity to Optimized Lead Placement.medRxiv : the preprint server for health sciences · 2026Article
- Intrinsic and extrinsic connectivity of the seizure onset zone at rest and during stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.Epilepsia · 2025Review
- Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain.Brain structure & function · 2025Article
- Surgical targeting of lateralizedEpilepsia · 2025Article
- From Bedside to Desktop: A Data Protocol for Normative Intracranial EEG and Abnormality Mapping.Bio-protocol · 2025Article
- Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.Frontiers in network physiology · 2025Article
- Preictal connectivity dynamics: Exploring inflow and outflow in iEEG networks.Frontiers in network physiology · 2025Article
- Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection-hub alignment in interictal intracranial EEG networks.Epilepsia · 2024Article
- Utility of intracranial EEG networks depends on re-referencing and connectivity choice.Brain communications · 2024Article
- The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks?Brain communications · 2024Article
- Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy.Brain communications · 2024Article
- Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy.medRxiv : the preprint server for health sciences · 2023Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- Article
- Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery.Neurology · 2023Article
- Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivePredicting postoperative seizure freedom using functional correlation networks derived from interictal intracranial electroencephalography (EEG) has shown some success. However, there are important challenges to consider: (1) electrodes physically closer to each other naturally tend to be more correlated, causing a spatial bias; (2) implantation location and number of electrodes differ between patients, making cross-subject comparisons difficult; and (3) functional correlation networks can vary over time but are currently assumed to be static.
methodsIn this study, we address these three challenges using intracranial EEG data from 55 patients with intractable focal epilepsy. Patients additionally underwent preoperative magnetic resonance imaging (MRI), intraoperative computed tomography, and postoperative MRI, allowing accurate localization of electrodes and delineation of the removed tissue.
resultsWe show that normalizing for spatial proximity between nearby electrodes improves prediction of postsurgery seizure outcomes. Moreover, patients with more extensive electrode coverage were more likely to have their outcome predicted correctly (area under the receiver operating characteristic curve > 0.9, P « 0.05) but not necessarily more likely to have a better outcome. Finally, our predictions are robust regardless of the time segment analyzed. SIGNIFICANCE: Future studies should account for the spatial proximity of electrodes in functional network construction to improve prediction of postsurgical seizure outcomes. Greater coverage of both removed and spared tissue allows for predictions with higher accuracy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.