Evidence map›Paper›PMID 32588909›Full record

ArticleBiometrics2021

Parametric g-formula implementations for causal survival analyses.

Lan Wen, Jessica G Young, James M Robins, Miguel A Hernán

Abstract read
In one paragraph

Article in Biometrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Flexible Survival Extrapolation with Blended Hazards: Accounting for Treatment Effect Waning in Health Technology Assessment.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lan WenDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-6120-8492
Jessica G YoungDepartment of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
James M RobinsDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Miguel A HernánDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Funding

Dynamic Strategies for the clinical management of HIV diseaseR37AI102634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MIGUEL HERNAN · 2018 to 2026
$5.3M
Dynamic strategies for the clinical management of HIV diseaseR01AI102634 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HERNAN, MIGUEL · 2013 to 2017
$2.6M
NIAID NIH HHS R01 AI102634NIAID NIH HHS R37 AI102634
6 · The paper itself

Abstract

The g-formula can be used to estimate the survival curve under a sustained treatment strategy. Two available estimators of the g-formula are noniterative conditional expectation and iterative conditional expectation. We propose a version of the iterative conditional expectation estimator and describe its procedures for deterministic and random treatment strategies. Also, because little is known about the comparative performance of noniterative and iterative conditional expectation estimators, we explore their relative efficiency via simulation studies. Our simulations show that, in the absence of model misspecification and unmeasured confounding, our proposed iterative conditional expectation estimator and the noniterative conditional expectation estimator are similarly efficient, and that both are at least as efficient as the classical iterative conditional expectation estimator. We describe an application of both noniterative and iterative conditional expectation to answer "when to start" treatment questions using data from the HIV-CAUSAL Collaboration.

Indexed as

Models, StatisticalCausalityComputer SimulationSurvival Analysiscausal inferencedeterministic dynamic regimesg-formularandom dynamic regimessurvival analysis

Identifiers

PMID32588909
PMCPMC9044498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.