Evidence map›Paper›PMID 32588524›Full record

ArticleJournal of cellular and molecular medicine2020

Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis.

Chi Zhang, Yinuo Lin, Qi Liu, Junhua He, Pingping Xiang, Dianliang Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Hong Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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  15. State of the field: cellular and exosomal therapeutic approaches in vascular regeneration.American journal of physiology. Heart and circulatory physiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chi ZhangDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yinuo LinDepartment of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qi LiuDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Junhua HeDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Pingping XiangDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Dianliang WangStem Cell and Tissue Engineering Research Laboratory, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Xinyang HuDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Jinghai ChenDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Wei ZhuDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Hong YuDepartment of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0001-6664-7817
Second Affiliated Hospital of Zhejiang University · CNCell Technology (China) · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family. It has multiple effects on development, physiology and diseases. However, the role of GDF11 in the development of mesenchymal stem cells (MSCs) is not clear. To explore the effects of GDF11 on the differentiation and pro-angiogenic activities of MSCs, mouse bone marrow-derived MSCs were engineered to overexpress GDF11 (MSC

Indexed as

AnimalsApoptosisBone Morphogenetic ProteinsCell DifferentiationCell MovementCells, CulturedEndothelial CellsGene ExpressionGrowth Differentiation FactorsHypoxiaMaleMAP Kinase Signaling SystemMesenchymal Stem CellsMiceNeovascularization, PhysiologicVascular Endothelial Growth Factor ABone Morphogenetic ProteinsGdf11 protein, mouseGrowth Differentiation FactorsVascular Endothelial Growth Factor Aangiogenesisangiogenic therapydifferentiationendothelial cellsGDF11mesenchymal stem cells

Identifiers

PMID32588524
PMCPMC7412688
OpenAlexW3037452599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.