Evidence map›Paper›PMID 32588379›Full record

ArticleIrish journal of medical science2021

Glycaemic control improves after continuous subcutaneous insulin infusion therapy: results from an Irish regional centre for paediatric type 1 diabetes mellitus.

Khubaib Ahmed, Clodagh S O'Gorman, Orla M Neylon, Jean Saunders, Marguerite Lawler, Anne Quinn, Marry Norris, Maria Conroy-Kelly, Therese Dunne

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Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Khubaib AhmedPaediatric Registrar, University Hospital Limerick, Limerick, Ireland. khobibhajo@hotmail.com.
Clodagh S O'GormanPaediatric Department, University Hospital Limerick, Limerick, Ireland.
Orla M NeylonPaediatric Department, University Hospital Limerick, Limerick, Ireland.
Jean SaundersStatistical Consulting Unit/CSTAR, University of Limerick, Limerick, Ireland.
Marguerite LawlerPaediatric Registrar, University Hospital Limerick, Limerick, Ireland.
Anne QuinnPaediatric Department, University Hospital Limerick, Limerick, Ireland.
Marry NorrisPaediatric Department, University Hospital Limerick, Limerick, Ireland.
Maria Conroy-KellyPaediatric Department, University Hospital Limerick, Limerick, Ireland.
Therese DunnePaediatric Department, University Hospital Limerick, Limerick, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe use of continuous subcutaneous insulin infusion (CSII) in the management of paediatric patients with type 1 diabetes mellitus (T1DM) has increased substantially in the last decade. The aim of this study was to evaluate and compare glycaemic control in a population of paediatric patients with T1DM before commencing CSII compared with 2 years after commencing CSII.

methodsThis is a retrospective study with data collection from diabetes clinic records. Complete data were obtained on 34/45 eligible patients. Glycosylated haemoglobin (HbA1c) and body mass index (BMI) were compared 6 months pre- and 2 years post CSII commencement. Data were stratified in 6-month blocks.

resultsMean HbA1c improved over 2 years post CSII with the lowest value in the first 6 months post-commencement. When gender, age, time since diagnosis and time on pump were added as covariates, results became non-significant, with only age exhibiting a statistically significant influence on glycaemic control (p = 0.03). This improved glycaemic control is associated with some increment in BMI which showed no statistical significance in the first year post-CSII.

conclusionCSII commencement is associated with significantly improved glycaemic control most notably in the first 6 months after CSII commencement. There is association between CSII commencement and increased BMI noted to be statistically significant in the second year.

Indexed as

ChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGlycemic ControlHumansHypoglycemic AgentsInfusions, SubcutaneousInsulinIrelandMaleRetrospective StudiesHypoglycemic AgentsInsulinInsulinPaediatric diabetes

Identifiers

PMID32588379

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.