Evidence map›Paper›PMID 32588343›Full record

ArticleGeroScience2021

Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading.

Marcus M Lawrence, Douglas W Van Pelt, Amy L Confides, Zachary R Hettinger, Emily R Hunt, Justin J Reid, Jaime L Laurin, Frederick F Peelor, Timothy A Butterfield, Benjamin F Miller and 1 more

Open access · greenAbstract read
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 15 citations in OpenAlex.

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  16. Age-Related Susceptibility to Muscle Damage Following Mechanotherapy in Rats Recovering From Disuse Atrophy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  17. Massage as a Mechanotherapy for Skeletal Muscle.Exercise and sport sciences reviews · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Marcus M LawrenceAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Douglas W Van PeltDepartment of Physical Therapy, University of Kentucky, Lexington, KY, 40536, USA.
Amy L ConfidesDepartment of Physical Therapy, University of Kentucky, Lexington, KY, 40536, USA.
Zachary R HettingerDepartment of Physical Therapy, University of Kentucky, Lexington, KY, 40536, USA.
Emily R HuntDepartment of Physical Therapy, University of Kentucky, Lexington, KY, 40536, USA.
Justin J ReidAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Jaime L LaurinAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Frederick F PeelorAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Timothy A ButterfieldCenter for Muscle Biology, University of Kentucky, Lexington, KY, 40536, USA.
Benjamin F MillerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Esther E Dupont-VersteegdenDepartment of Physical Therapy, University of Kentucky, Lexington, KY, 40536, USA. esther.dupont@uky.edu.ORCID http://orcid.org/0000-0001-5576-9659
University of Kentucky · USOklahoma Medical Research Foundation · US

Funding

NRSA Training CoreTL1TR001997 · NCATS · UNIVERSITY OF KENTUCKY · PI PENDERGAST, JULIE S, STOOPS, WILLIAM WALTON · 2016 to 2025
$4.2M
GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
Mechanisms underlying anabolic effects of cyclic compressive loading in muscleR01AT009268 · NCCIH · UNIVERSITY OF KENTUCKY · PI BUTTERFIELD, TIMOTHY ALAN, DUPONT-VERSTEEGDEN, ESTHER E · 2017 to 2021
$2.3M
Cyclic compressive loading to negate atrophy and impaired regrowth in aged muscleR21AG042699 · NIA · UNIVERSITY OF KENTUCKY · PI BUTTERFIELD, TIMOTHY ALAN, DUPONT-VERSTEEGDEN, ESTHER E · 2013 to 2014
$412k
NCATS NIH HHS TL1 TR001997NCCIH NIH HHS R01 AT009268NIA NIH HHS R21 AG042699NIA NIH HHS T32 AG052363
6 · The paper itself

Abstract

Massage is a viable mechanotherapy to improve protein turnover during disuse atrophy and improve muscle regrowth during recovery from disuse atrophy in adult muscle. Therefore, we investigated whether massage can cause beneficial adaptations in skeletal muscle from aged rats during normal weight-bearing (WB) conditions, hindlimb suspension (HS), or reloading (RE) following HS. Aged (30 months) male Fischer 344/Brown Norway rats were divided into two experiments: (1) WB for 7 days (WB, n = 8), WB with massage (WBM, n = 8), HS for 7 days (HS7, n = 8), or HS with massage (HSM, n = 8), and (2) WB for 14 days (WB14, n = 8), HS for 14 days (HS14, n = 8), reloading (RE, n = 10), or reloading with massage (REM, n = 10) for 7 days following HS. Deuterium oxide (D

Indexed as

Hindlimb SuspensionMuscular AtrophyAnimalsMaleMuscle, SkeletalRatsRats, Inbred BNRats, Inbred F344AgingDisuse atrophyMechanotherapyProtein turnoverRibosome biogenesis

Identifiers

PMID32588343
PMCPMC8050124
OpenAlexW3037462641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.