Evidence map›Paper›PMID 32588329›Full record

ReviewCurrent nutrition reports2020

Effects of Non-nutritive Sweeteners on Sweet Taste Processing and Neuroendocrine Regulation of Eating Behavior.

Alexandra G Yunker, Reshma Patel, Kathleen A Page

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current nutrition reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Food sweeteners: Angels or clowns for human health?Current research in food science · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexandra G YunkerDivision of Endocrinology, Department of Medicine, Keck School of Medicine, Diabetes and Obesity Research Institute, University of Southern California, 2250 Alcazar Street; CSC 209, Los Angeles, CA, 90089, USA.
Reshma PatelDivision of Endocrinology, Department of Medicine, Keck School of Medicine, Diabetes and Obesity Research Institute, University of Southern California, 2250 Alcazar Street; CSC 209, Los Angeles, CA, 90089, USA.
Kathleen A PageDivision of Endocrinology, Department of Medicine, Keck School of Medicine, Diabetes and Obesity Research Institute, University of Southern California, 2250 Alcazar Street; CSC 209, Los Angeles, CA, 90089, USA. kpage@usc.edu.ORCID 0000-0002-9083-6615
University of Southern California · US

Funding

Neural Mechanisms for Appetitive Responses to High Reward FoodsR01DK102794 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA · 2016 to 2020
$2.7M
NIDDK NIH HHS R01 DK102794
6 · The paper itself

Abstract

purpose of reviewNon-nutritive sweeteners (NNS) are increasingly used as a replacement for nutritive sugars as means to quench the desire for "sweets" while contributing few or no dietary calories. However, there is concern that NNS may uncouple the evolved relationship between sweet taste and post-ingestive neuroendocrine signaling. In this review, we examine the effects of NNS exposure on neural and peripheral systems in humans. RECENT

findingsNNS exposure during early development may influence sweet taste preferences, and NNS consumption might increase motivation for sweet foods. Neuroimaging studies provide evidence that NNS elicit differential neuronal responsivity in areas related to reward and satiation, compared with caloric sweeteners. Findings are heterogenous regarding whether NNS affect physiological responses. Additional studies are warranted regarding the consequences of NNS on metabolic outcomes and neuroendocrine pathways. Given the widespread popularity of NNS, future studies are essential to establish their role in long-term health.

Indexed as

EatingEnergy IntakeHumansSatiationSweetening AgentsTasteSweetening AgentsAmygdalaAppetiteArtificial sweetenersBrainFeeding behaviorfMRIFood intakeGLP-1HormonesHypothalamusIncretinsInsulaInsulinLow-calorie sweetenersNeuroimagingNon-nutritive sweetenersObesityRewardSatietyStriatumSweetenersSweet taste

Identifiers

PMID32588329
OpenAlexW3037538987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.