ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2021
Recording and quantifying sympathetic outflow to muscle and skin in humans: methods, caveats and challenges.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 65 citations in OpenAlex.
- Acute Effects of Resonance Breathing on Skin Sympathetic Nerve Activity and Heart Rate Variability in Healthy Adults.Applied psychophysiology and biofeedback · 2025Trial
- Low-dose morphine reduces pain perception and blood pressure, but not muscle sympathetic outflow, responses during the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- First in-human microelectrode recordings of vagus nerve activity in heart failure.The Journal of physiology · 2026Article
- Autonomic effects of simulated periodic breathing in patients with chronic heart failure on contemporary guideline-directed therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Article
- The autonomic nervous system in the regulation of glucose and lipid metabolism.Nature reviews. Endocrinology · 2026Review
- Hyperadrenergic postural tachycardia syndrome associated with augmented neurovascular transduction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Cortical excitation does not drive changes in skin sympathetic nerve activity during single-pulse transcranial magnetic stimulation in humans.Experimental brain research · 2026Article
- Emergent technologies in clinical neurophysiology to study the neuromuscular system: IFCN handbook chapter.Clinical neurophysiology practice · 2026Review
- Liver-nervous system axis in MASLD: mechanistic insights and emerging targeted therapies.eGastroenterology · 2026Review
- Tracing Human Sympathetic Cardiovascular Control Mechanism in the Brain.Current hypertension reports · 2025Review
- The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Diastolic Blood Pressure Rise During Valsalva as a Surrogate for Sympathetic Activation to Identify Functional Hyperadrenergic Postural Tachycardia Syndrome.Research square · 2025Article
- Spike detection of human sympathetic nerve activity using wavelet transformation and Valsalva maneuver denoising.Journal of neuroscience methods · 2025Article
- Risk of bradycardia and asystole during microelectrode recordings from the human vagus nerve.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Firing properties of single axons with cardiac rhythmicity in the human cervical vagus nerve.The Journal of physiology · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of microneurography, in which the electrical activity of axons can be recorded via an intrafascicular microelectrode inserted through the skin into a peripheral nerve in awake human participants, has contributed a great deal to our understanding of sensorimotor control and the control of sympathetic outflow to muscle and skin. This review summarises the different approaches to recording muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA), together with discussion on the issues that determine the quality of a recording. Various analytical approaches are also described, with a primary emphasis on those developed by the author, aimed at maximizing the information content from recordings of postganglionic sympathetic nerve activity in awake humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.