Evidence map›Paper›PMID 32588218›Full record

ArticleEuropean journal of nutrition2021

Serum choline in extremely preterm infants declines with increasing parenteral nutrition.

Anders K Nilsson, Anders Pedersen, Daniel Malmodin, Anna-My Lund, Gunnel Hellgren, Chatarina Löfqvist, Ingrid Hansen Pupp, Ann Hellström

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02760472 (A Randomised Intervention Single Center Study to Determine the Role of Fatty Acids in Serum in Preventing Retinopathy of Prematurity), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02760472 phase3completednot on this map

A Randomised Intervention Single Center Study to Determine the Role of Fatty Acids in Serum in Preventing Retinopathy of Prematurity

TypeinterventionalSponsorCarola Pfeiffer-MosessonRan2013 to 2015Enrolled90ConditionsRetinopathy of PrematurityArmsSMOFlipid, Clinoleic
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. The use of choline supplementation in premature newborns: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anders K NilssonSection for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. anders.k.nilsson@gu.se.ORCID http://orcid.org/0000-0003-3631-0783
Anders PedersenSwedish NMR Centre, University of Gothenburg, Gothenburg, Sweden.
Daniel MalmodinSwedish NMR Centre, University of Gothenburg, Gothenburg, Sweden.
Anna-My LundDepartment of Clinical Sciences Lund, Pediatrics, Lund University, Skane University Hospital, Lund, Sweden.
Gunnel HellgrenSection for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Chatarina LöfqvistSection for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ingrid Hansen PuppDepartment of Clinical Sciences Lund, Pediatrics, Lund University, Skane University Hospital, Lund, Sweden.
Ann HellströmSection for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SELund University · SE

Funding

Carmen och Bertil Regnérs Stiftelse för Forskning inom Ögonsjukdomar 2016-00022De Blindas Vänner 72/16Magnus Bergvalls Stiftelse 2016-01492Vetenskapsrådet 2015-00810
6 · The paper itself

Abstract

purposeCholine is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and how the concentrations were affected by the proportion of parenteral fluids the infants received during the first 28 postnatal days (PNDs).

methodsThis prospective study included 87 infants born at gestational age (GA) < 28 weeks. Infant serum samples were collected PND 1, 7, 14, and 28, and at postmenstrual age (PMA) 32, 36, and 40 weeks. The serum concentrations of free choline, betaine, and methionine were determined by

resultsThe median (25th-75th percentile) serum concentrations of free choline, betaine, and methionine were 33.7 (26.2-41.2), 71.2 (53.2-100.8), and 25.6 (16.4-35.3) µM, respectively, at PND 1. The choline concentration decreased rapidly between PND one and PND seven [18.4 (14.1-26.4) µM], and then increased over the next 90 days, though never reaching PND one levels. There was a negative correlation between a high intake of parenteral fluids and serum-free choline.

conclusionCirculating free choline in extremely preterm infants is negatively affected by the proportion of parenteral fluids administered.

trial registrationClinicalTrials.gov Identifier NCT02760472, April 29, 2016, retrospectively registered.

Indexed as

CholineInfant, Extremely PrematureBetaineHumansInfantInfant, NewbornParenteral NutritionProspective StudiesBetaineCholineBetaineEnteral nutritionHuman milkMethioninePhosphatidylcholineProton nuclear magnetic resonance

Identifiers

PMID32588218
PMCPMC7900091
OpenAlexW3037465667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.