ArticleThe EMBO journal1988
Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 158 citations in OpenAlex.
- Revisiting the role of Annexins in membrane trafficking.Cellular and molecular life sciences : CMLS · 2025Review
- Annexin V expression on CD4Immunology · 2020Article
- Augmentation of gonadotropin-releasing hormone receptor expression in the post-lactational mammary tissues of rats.The Journal of reproduction and development · 2016Article
- A note on protein expression changes in chicken breast muscle in response to time in transit before slaughtering.Proteome science · 2013Article
- Identification of cytoskeleton-associated proteins in isolated rat liver endosomes.The Biochemical journal · 1997Article
- Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells.British journal of cancer · 1995Article
- Expression and characterization of a Dictyostelium discoideum annexin.Molecular and cellular biochemistry · 1994Article
- Structure of the human annexin VI gene.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Endocytosis occurs independently of annexin VI in human A431 cells.The Journal of cell biology · 1994Article
- Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat.Nucleic acids research · 1992Article
- Distinct cellular expression pattern of annexins in Hydra vulgaris.The Journal of cell biology · 1992Article
- Properties and partial protein sequence of plant annexins.Plant physiology · 1992Article
- Expression of annexin VI (p68, 67 kDa-calelectrin) in normal human tissues: evidence for developmental regulation in B- and T-lymphocytes.Histochemistry · 1991Article
- The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes.The EMBO journal · 1990Article
- cDNA structure and expression of calpactin, a peptide involved in Ca2(+)-dependent cell aggregation in sponges.The Biochemical journal · 1990Article
- Purification and partial sequence analysis of plant annexins.The Biochemical journal · 1990Article
- Monoclonal antibodies specific to a Ca2(+)-bound form of lipocortin I distinguish its Ca2(+)-dependent phospholipid-binding ability from its ability to inhibit phospholipase A2.The Biochemical journal · 1990Article
- Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins.The Biochemical journal · 1990Article
- A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation.The Biochemical journal · 1989Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cDNA clones encoding human 'p68', a membrane-associated Ca2+-binding protein, were isolated from a lambda gt11 expression library of the human T-leukaemia cell line J6, by using a rabbit antiserum against denatured purified lymphocyte p68, and from a liver cDNA library by using 32P-labelled p68 cDNA fragments. The amino acid sequence of p68, deduced from the sequences of overlapping cDNA clones, is described. The results show that p68 is closely related to a family of proteins which includes intracellular substrates of the EGF receptor and pp60src tyrosine kinases. The p68 amino acid sequence is internally repetitive, being constructed from eight repeats of varying lengths, each of which contains a highly conserved sequence. Multiple copies of the latter sequence are also present in the related proteins p36, lipocortin I and protein II. We discuss how the common structural features of these proteins may reflect common functions and, furthermore, how the eight repeat structure of p68 may have evolved. The sequences of independent cDNAs suggest that alternatively-spliced mRNAs could encode different p68 protein species. This suggestion is consistent with the observation that purified p68 migrates as a closely-spaced doublet when analysed by SDS-PAGE.
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