Evidence map›Paper›PMID 32588075›Full record

ArticleInternational urogynecology journal2021

Sacral neuromodulation for overactive bladder in women: do age and comorbidities make a difference?

Rachel A High, William Winkelman, Joseph Panza, Derrick J Sanderson, Hyde Yuen, Gabriela Halder, Courtney Shaver, Erin T Bird, Rebecca G Rogers, Jill M Danford

Abstract read
PubMed Publisher
In one paragraph

Article in International urogynecology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Sacral neuromodulation in the golden years: Treatment outcomes in elderly 75 years and older.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Rachel A HighDepartment of Obstetrics and Gynecology, Baylor Scott & White Health, 2401 South 31st Street, Temple, TX, 76508, USA. Rachel.High@bswhealth.org.ORCID http://orcid.org/0000-0002-3717-0893
William WinkelmanDepartment of Obstetrics and Gynecology, Mount Auburn Hospital, Cambridge, and the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, and the Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
Joseph PanzaDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Derrick J SandersonDepartment of Obstetrics and Gynecology University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.
Hyde YuenDepartment of Obstetrics and Gynecology, Christ Hospital, Cincinnati, OH, USA.
Gabriela HalderDell School of Medicine, University of Texas, Austin, TX, USA.
Courtney ShaverOffice of Biostatistics Baylor Scott & White, Temple, TX, USA.
Erin T BirdDepartment of Urology Baylor Scott & White Health, Temple, TX, USA.
Rebecca G RogersDell School of Medicine, University of Texas, Austin, TX, USA.
Jill M DanfordDepartment of Urology Baylor Scott & White Health, Temple, TX, USA.
Baylor Scott & White Health · USThe University of Texas at Austin · USBaylor Medical Center at Garland · USChrist Hospital · USMount Auburn Hospital · USUniversity of Rochester · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate if age and comorbidities are associated with progression from trial phase to implantation of an implantable pulse generator in women with overactive bladder.

methodsThis multisite retrospective cohort included women with overactive bladder with or without urinary incontinence who had a trial phase for sacral neuromodulation. The primary outcome was progression to implantation. A sub-analysis of implanted patients was performed for the outcome of additional therapies or "implant only" for the duration of follow-up. Multivariate logistic regression models including potential predictors of implantation and post-implantation addition of therapies were performed.

resultsAt six academic institutions, 91% (785/864) of patients progressed to implantation. Post-implantation success was achieved by 69% (536/782) of patients at median follow-up of 2 (range 0.3 to 15) years. Odds of implantation [OR 0.73 (CI 0.61, 0.88)] and post-implantation success [OR 0.78 (CI 0.98, 0.97)] were lower with increasing decades of age. Medical comorbidities evaluated did not affect implantation rates or post-implant success.

conclusionsMost women have successful sacral neuromodulation trials despite older age and comorbidities. Higher decade of age has a negative effect on odds of implantation and is associated with addition of therapies post-implantation. Comorbidities assessed in this study did not affect implantation or addition of therapies post-implantation. Most women add therapies to improve efficacy post-implantation, and explantation rates are low.

Indexed as

Electric Stimulation TherapyUrinary Bladder, OveractiveAgedFemaleHumansLumbosacral PlexusRetrospective StudiesSacrumTreatment OutcomeAgingElderlyOveractive bladderSacral neuromodulationUrinary incontinence

Identifiers

PMID32588075
OpenAlexW3037260934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.