ArticleInternational journal of epidemiology2020
Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study.
Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease.American journal of respiratory and critical care medicine · 2023Pooled it
- Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study.European journal of epidemiology · 2022Pooled it
- Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.BMC medicine · 2021Pooled it
- Causal Relationships Between Modifiable Risk Factors and Gastroesophageal Reflux Disease: A Two-Sample Mendelian Randomization Study.Current medicinal chemistry · 2026Article
- Colorectal cancer risk stratification using a polygenic risk score in symptomatic primary care patients-a UK Biobank retrospective cohort study.European journal of human genetics : EJHG · 2024Article
- Socioeconomic traits and the risk of Barrett's esophagus and gastroesophageal reflux disease: A Mendelian randomization study.World journal of gastrointestinal oncology · 2024Article
- Hyperglycaemia is a causal risk factor for upper limb pathologies.International journal of epidemiology · 2024Article
- Causal analysis between gastro-oesophageal reflux disease and obstructive sleep apnoea.ERJ open research · 2023Article
- Depression Promotes Gastroesophageal Reflux Disease: New Evidence Based on Mendelian Randomization.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Association of educational attainment with esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease, and the mediating role of modifiable risk factors: A Mendelian randomization study.Frontiers in public health · 2023Article
- Body Composition and COPD: A New Perspective.International journal of chronic obstructive pulmonary disease · 2023Review
- Shift work and risk of incident gastroesophageal reflux disease: the association and mediation.Frontiers in public health · 2023Article
- Article
- Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update.Nutrients · 2022Review
- Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease.Frontiers in nutrition · 2022Article
- Association between the body mass index, waist circumference, and body fat percentage with erosive esophagitis in adults with obesity after sleeve gastrectomy.F1000Research · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGastro-oesophageal reflux disease (GORD) is associated with multiple risk factors but determining causality is difficult. We used a genetic approach [Mendelian randomization (MR)] to identify potential causal modifiable risk factors for GORD.
methodsWe used data from 451 097 European participants in the UK Biobank and defined GORD using hospital-defined ICD10 and OPCS4 codes and self-report data (N = 41 024 GORD cases). We tested observational and MR-based associations between GORD and four adiposity measures [body mass index (BMI), waist-hip ratio (WHR), a metabolically favourable higher body-fat percentage and waist circumference], smoking status, smoking frequency and caffeine consumption.
resultsObservationally, all adiposity measures were associated with higher odds of GORD. Ever and current smoking were associated with higher odds of GORD. Coffee consumption was associated with lower odds of GORD but, among coffee drinkers, more caffeinated-coffee consumption was associated with higher odds of GORD. Using MR, we provide strong evidence that higher WHR and higher WHR adjusted for BMI lead to GORD. There was weak evidence that higher BMI, body-fat percentage, coffee drinking or smoking caused GORD, but only the observational effects for BMI and body-fat percentage could be excluded. This MR estimated effect for WHR equates to a 1.23-fold higher odds of GORD per 5-cm increase in waist circumference.
conclusionsThese results provide strong evidence that a higher waist-hip ratio leads to GORD. Our study suggests that central fat distribution is crucial in causing GORD rather than overall weight.
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Registered trials
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