ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Personality Associations With Amyloid and Tau: Results From the Baltimore Longitudinal Study of Aging and Meta-analysis.Biological psychiatry · 2022Pooled it
- Using objective and subjective measures of mind wandering to predict progression to development of cognitive impairment and test associations with Alzheimer disease biomarkers.Journal of clinical and experimental neuropsychology · 2025Article
- Article
- Personality, Aging, and Alzheimer's Disease: Implications for Psychoneuroimmunology and Personalized Medicine.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Personality traits and measures of neuropsychiatric symptoms.Aging & mental health · 2025Article
- High-frequency assessment of mood, personality, and cognition in healthy younger, healthy older and adults with cognitive impairment.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
- Associations between personality and psychological characteristics and cognitive outcomes among older adults.Psychology and aging · 2024Article
- Dispositional traits help explain individual differences in relationships between a radiographic knee osteoarthritis measure, pain, and physical function.Therapeutic advances in musculoskeletal disease · 2024Article
- Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.International psychogeriatrics · 2022Observational
- Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.Scientific reports · 2022Article
- Early-Onset Alzheimer's Disease: What Is Missing in Research?Current neurology and neuroscience reports · 2021Review
- Neuroticism Is Associated with Tau Pathology in Cognitively Unimpaired Individuals with Autosomal Dominant Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- The relationship between personality traits and Alzheimer's disease: a narrative review.Frontiers in neurologyReview
- The Influence of Personality Traits on Driving Behaviors in Preclinical Alzheimer Disease.Alzheimer disease and associated disordersArticle
- Changes in personality traits in patients with Alzheimer's Disease.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
23 authors at 9 institutions in 4 countries.
Funding
Abstract
introductionChanges in personality characteristics are associated with the onset of symptoms in Alzheimer's disease (AD) and may even precede clinical diagnosis. However, personality changes caused by disease progression can be difficult to separate from changes that occur with normal aging. The Dominantly Inherited Alzheimer Network (DIAN) provides a unique cohort in which to relate measures of personality traits to in vivo markers of disease in a much younger sample than in typical late onset AD.
methodsPersonality traits measured with the International Personality Item Pool at baseline from DIAN participants were analyzed as a function of estimated years to onset of clinical symptoms and well-established AD biomarkers.
resultsBoth neuroticism and conscientiousness were correlated with years to symptom onset and markers of tau pathology in the cerebrospinal fluid. Self-reported conscientiousness and both neuroticism and conscientiousness ratings from a collateral source were correlated with longitudinal rates of cognitive decline such that participants who were rated as higher on neuroticism and lower on conscientiousness exhibited accelerated rates of cognitive decline. DISCUSSION: Personality traits are correlated with the accumulation of AD pathology and time to symptom onset, suggesting that AD progression can influence an individual's personality characteristics. Together these findings suggest that measuring neuroticism and conscientiousness may hold utility in tracking disease progression in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.