Evidence map›Paper›PMID 32587658›Full record

ArticleOxidative medicine and cellular longevity2020

Club Cell Heme Oxygenase-1 Deletion: Effects in Hyperoxia-Exposed Adult Mice.

Katelyn Dunigan-Russell, Mary Silverberg, Vivian Y Lin, Rui Li, Stephanie B Wall, Qian Li, Teodora Nicola, John Gotham, David R Crowe, Peter F Vitiello and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katelyn Dunigan-RussellDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
Mary SilverbergDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
Vivian Y LinDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
Rui LiDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
Stephanie B WallDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
Qian LiDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
Teodora NicolaDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
John GothamDivision of Neonatology, Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama, USA.
David R CroweUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Peter F VitielloDepartment of Pediatrics, University of South Dakota Sanford School of Medicine, Sanford Research, Sioux Falls, ND, USA.ORCID https://orcid.org/0000-0001-5344-9192
Anupam AgarwalUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Trent E TippleSection of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Oklahoma, Oklahoma City, OK, USA.ORCID https://orcid.org/0000-0002-5156-4282

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
Hyperoxic Modulation of Thioredoxin SignalingR01HL135112 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI VITIELLO, PETER · 2017 to 2021
$2.0M
NHLBI NIH HHS R01 HL135112NIGMS NIH HHS P20 GM103620
6 · The paper itself

Abstract

Thioredoxin reductase-1 (TXNRD1) inhibition activates nuclear factor (erythroid-derived 2)-like 2 (Nrf2) responses and prevents acute lung injury (ALI). Heme oxygenase-1 (HO-1) induction following TXNRD1 inhibition is Nrf2-dependent in airway epithelial (club) cells

Indexed as

Gene DeletionAgingAnimalsAnimals, NewbornCrosses, GeneticEpithelial CellsFemaleGenotypeHeme Oxygenase-1HyperoxiaIntegrasesLungLung InjuryMaleMice, Inbred C57BLMice, TransgenicCre recombinaseHeme Oxygenase-1IntegrasesScgb1a1 protein, mouseUteroglobin

Identifiers

PMID32587658
PMCPMC7303751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.