Evidence map›Paper›PMID 32587657›Full record

ArticleOxidative medicine and cellular longevity2020

Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts.

Yuxuan Zheng, Michael L Merchant, Tom J Burke, Jeffrey D Ritzenthaler, Ming Li, Adam E Gaweda, Frederick W Benz, Jesse Roman, Walter H Watson

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuxuan ZhengDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.ORCID https://orcid.org/0000-0002-2109-331X
Michael L MerchantDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Tom J BurkeDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, 40202 KY, USA.
Jeffrey D RitzenthalerDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Sidney Kimmel Medical College and Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, 19107 PA, USA.
Ming LiDepartment of Medicine, Division of Nephrology and Hypertension, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Adam E GawedaDepartment of Medicine, Division of Nephrology and Hypertension, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Frederick W BenzDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Jesse RomanDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Sidney Kimmel Medical College and Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, 19107 PA, USA.
Walter H WatsonDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.ORCID https://orcid.org/0000-0002-4381-1087
University of Louisville · USThomas Jefferson University · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
NIAAA NIH HHS P50 AA024337NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Slc7a11 is the key component of system X

Indexed as

AgingAmino Acid Transport System y+AnimalsCellular SenescenceCystineCytoskeletonFemaleFibroblastsGene OntologyLungMiceMice, Inbred C57BLOxidation-ReductionProtein Interaction MapsAmino Acid Transport System y+CystineSlc7a11 protein, mouse

Identifiers

PMID32587657
PMCPMC7298344
OpenAlexW3035115359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.