Evidence map›Paper›PMID 32587653›Full record

ArticleJournal of clinical medicine research2020

Purifying Selection in Human Immunodeficiency Virus-1

Ralph-Sydney Mboumba Bouassa, Helene Pere, Christian Diamant Mossoro-Kpinde, Pierre Roques, Jean Chrysostome Gody, Sandrine Moussa, David Veyer, Gerard Gresenguet, Charlotte Charpentier, Mohammad-Ali Jenabian and 2 more

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Article in Journal of clinical medicine research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Ralph-Sydney Mboumba BouassaLaboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
Helene PereLaboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
Christian Diamant Mossoro-KpindeFaculte des Sciences de la Sante, Universite de Bangui, Bangui, Central African Republic.
Pierre RoquesCommissariat a l'Energie Atomique (CEA)-Universite Paris-Saclay; INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department, Institut de Biologie Francois-Jacob (IBJF), Fontenay-aux-Roses, France.
Jean Chrysostome GodyFaculte des Sciences de la Sante, Universite de Bangui, Bangui, Central African Republic.
Sandrine MoussaInstitut Pasteur de Bangui, Bangui, Central African Republic.
David VeyerLaboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
Gerard GresenguetFaculte des Sciences de la Sante, Universite de Bangui, Bangui, Central African Republic.
Charlotte CharpentierIAME, UMR 1137, INSERM, Universite Paris Diderot, Sorbonne Paris Cite, AP-HP, Laboratoire de Virologie, Hopital Bichat, AP-HP, Paris, France.
Mohammad-Ali JenabianDepartement des Sciences Biologiques et Centre de Recherche BioMed, Universite du Quebec a Montreal (UQAM), Montreal, QC, Canada.
Joel Fleury Djoba SiawayaEcole Doctorale Regionale en Infectiologie Tropicale, Franceville, Gabon.
Laurent BelecLaboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
University of Bangui · CFMère et Enfant en Milieu Tropical · FRAssistance Publique – Hôpitaux de Paris · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHôpital Européen Georges-Pompidou · FRInstitut Pasteur de Bangui · CFSorbonne Paris Cité · FRUniversité du Québec à Montréal · CAUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiological monitoring of antiretroviral treatment (ART) in human immunodeficiency virus (HIV)-infected pediatric population remains challenging. The aim of the present study was to assess the long-term HIV-1 genetic diversity in

methodsHIV-1 diversity in

resultsThe immunological responses to ART basically corresponded to: 1) Full therapeutic failure with immunological (I

conclusionsChildren and adolescents in immunovirological therapeutic failure harbor positive selection of HIV-1 strains favoring diversifying in

Indexed as

AdolescentsChildrenHIV-1 pol geneImmunovirological dissociationNonsynonymous mutationsPurifying selectionSynonymous mutationsVirological failure

Identifiers

PMID32587653
PMCPMC7295550
OpenAlexW3033516197

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.