Evidence map›Paper›PMID 32587467›Full record

ArticleMediators of inflammation2020

Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1

Yi-Jen Peng, Ching-Tsung Peng, Yi-Hsuan Lin, Gu-Jiun Lin, Shing-Hwa Huang, Shyi-Jou Chen, Huey-Kang Sytwu, Chia-Pi Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Research Progress of DcR3 in the Diagnosis and Treatment of Sepsis.International journal of molecular sciences · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yi-Jen PengDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Ching-Tsung PengDepartment of Clinical Pharmacy, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan.
Yi-Hsuan LinDepartment and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Gu-Jiun LinDepartment and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Shing-Hwa HuangDepartment and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Shyi-Jou ChenDepartment and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-9580-4321
Huey-Kang SytwuDepartment and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.
Chia-Pi ChengDepartment and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1150-8777
National Defense Medical Center · TWTri-Service General Hospital · TWNational Health Research Institutes · TWTaoyuan Armed Forces General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInterleukin-1

methodsWe treated murine macrophages with DCR3 during receptor activator of nuclear factor kappa Β ligand- (RANKL-) plus IL-1

resultsDCR3 suppresses IL-1

conclusionsWe concluded that there is an inhibitory effect of DCR3 on osteoclastogenesis via ROS accumulation and ROS-induced Fas ligand, IL-1

Indexed as

AnimalsApoptosisCell DeathEnzyme-Linked Immunosorbent AssayFas Ligand ProteinFlow CytometryImmunoblottingInterleukin-1alphaInterleukin 1 Receptor Antagonist ProteinInterleukin-1 Receptor-Associated KinasesMiceOsteoclastsRAW 264.7 CellsReactive Oxygen SpeciesReceptors, Tumor Necrosis Factor, Member 6bTartrate-Resistant Acid PhosphataseFas Ligand ProteinInterleukin-1alphaInterleukin 1 Receptor Antagonist ProteinInterleukin-1 Receptor-Associated KinasesIrak4 protein, mouseReactive Oxygen SpeciesReceptors, Tumor Necrosis Factor, Member 6bTartrate-Resistant Acid Phosphatase

Identifiers

PMID32587467
PMCPMC7303756
OpenAlexW3035675870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.