Evidence map›Paper›PMID 32587457›Full record

ArticleMolecular vision2020

A systems genetics approach to revealing the

Shasha Li, Fuyi Xu, Lin Liu, Rong Ju, Jonas Bergquist, Qing Yin Zheng, Jia Mi, Lu Lu, Xuri Li, Geng Tian

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shasha LiMedicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China.
Fuyi XuDepartment of Genetics, Genomics and informatics, University of Tennessee Health Science Center, Memphis, TN.
Lin LiuMedicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China.
Rong JuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Jonas BergquistMedicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China.
Qing Yin ZhengTransformative Otology and Neuroscience Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Jia MiMedicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China.
Lu LuDepartment of Genetics, Genomics and informatics, University of Tennessee Health Science Center, Memphis, TN.
Xuri LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Geng TianMedicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, China.

Funding

Deciphering the Usher I protein interactome using a geneticapproachR01DC015111 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI ZHENG, QING Y · 2016 to 2020
$1.8M
NIDCD NIH HHS R01 DC015111
6 · The paper itself

Abstract

Purpose: Platelet-derived growth factor (PDGF) signaling is well known to be involved in vascular retinopathies. Among the PDGF family, the subunit B (PDGFB) protein is considered a promising therapeutic target. This study aimed to identify the genes and potential pathways through which PDGFB affects retinal phenotypes by using a systems genetics approach. Methods: Gene expression data had been previously generated in a laboratory for the retinas of 75 C57BL/6J(B6) X DBA/2J (BXD) recombinant inbred (RI) strains. Using this data, the genetic correlation method was used to identify genes correlated to Results: Conclusions: A systems genetics analysis revealed that

Indexed as

Gene Regulatory NetworksActivating Transcription Factor 4AnimalsDatabases, GeneticGene Expression ProfilingGene OntologyHepatocyte Nuclear Factor 4Intraocular PressureLymphokinesMAP Kinase Signaling SystemMiceMice, Inbred C57BLOligonucleotide Array Sequence AnalysisPlatelet-Derived Growth FactorProtein Interaction MapsQuantitative Trait LociActivating Transcription Factor 4Atf4 protein, mouseHepatocyte Nuclear Factor 4Hnf4a protein, mouseLymphokinesPdgfd protein, mousePlatelet-Derived Growth FactorVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouse

Identifiers

PMID32587457
PMCPMC7305692

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.