Evidence map›Paper›PMID 32587396›Full record

ArticleScientific reports2020

A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter.

Karen I Hannigan, Aaron P Bossey, Holly J L Foulkes, Bernard T Drumm, Salah A Baker, Sean M Ward, Kenton M Sanders, Kathleen D Keef, Caroline A Cobine

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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  9. CaPhysiological reviews · 2024
    Review
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  11. CaThe Journal of physiology · 2022
    Article
  12. CaAdvances in experimental medicine and biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Karen I HanniganDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Aaron P BosseyDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Holly J L FoulkesDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Bernard T DrummDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Salah A BakerDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Kathleen D KeefDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Caroline A CobineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA. ccobine@med.unr.edu.
University of Nevada, Reno · US

Funding

Control of motility in the internal anal sphincterR01DK078736 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 2010 to 2019
$3.4M
NIDDK NIH HHS R01 DK078736
6 · The paper itself

Abstract

The internal anal sphincter (IAS) generates phasic contractions and tone. Slow waves (SWs) produced by interstitial cells of Cajal (ICC) underlie phasic contractions in other gastrointestinal regions. SWs are also present in the IAS where only intramuscular ICC (ICC-IM) are found, however the evidence linking ICC-IM to SWs is limited. This study examined the possible relationship between ICC-IM and SWs by recording Ca

Indexed as

Anal CanalAnimalsCalciumCalcium SignalingChloride ChannelsInterstitial Cells of CajalMiceMuscle ContractionMuscle, SmoothCalciumChloride Channels

Identifiers

PMID32587396
PMCPMC7316801
OpenAlexW3038033799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.