ArticleScientific reports2020
Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The association of sarcopenia, possible sarcopenia and cognitive impairment: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Multidomain interventions for sarcopenia and cognitive flexibility in older adults for promoting healthy aging: a systematic review and meta-analysis of randomized controlled trials.Aging clinical and experimental research · 2024Pooled it
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Evaluating Physical Frailty as a Marker of Cognitive Health in Older Adults without Dementia.Journal of geriatric psychiatry and neurology · 2026Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Article
- Mild cognitive impairment has a direct effect on gait speed even when accounting for frailty.BMC geriatrics · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Gait speed and domain-specific cognitive performance in a diverse cohort of the oldest-old: the LifeAfter90 Study.GeroScience · 2026Article
- Physical fitness and cognitive function: a cross-sectional study among adults in Qatar.BMJ open · 2026Article
- Association of Skeletal Muscle Strength with Cognitive Performance After Metabolic Bariatric Surgery.Journal of clinical medicine · 2026Article
- Associations between independent or concurrent decline in upper and lower limb strength and cognitive impairment.BMC geriatrics · 2026Article
- Motor reaction time in older women with different degrees of sarcopenia: What do electroencephalograms show?Einstein (Sao Paulo, Brazil) · 2026Observational
- Brain functional connectivity characteristics at various levels of inhibitory function in elderly individuals with cognitive impairment.Scientific reports · 2025Article
- Psychomotor Speed and Fall Risk in Older Adults with Sarcopenia and Frailty: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring the role of Transcranial magnetic stimulation in cognitive impairment and sarcopenia: a narrative review.Frontiers in human neuroscience · 2025Review
- Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.American journal of translational research · 2025Article
- Influence of Obesity and Sociodemographic Features on the Physical Fitness of Breast Cancer Survivors.Geriatrics (Basel, Switzerland) · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to examine muscle strength, function and mass in relation to cognition in older men. This cross-sectional data-set included 292 men aged ≥60 yr. Handgrip strength (kg) was measured by dynamometry, gait speed by 4-metre walk (m/s) and appendicular lean mass (kg) by dual-energy x-ray absorptiometry. Cognition was assessed across four domains: psychomotor function, attention, visual learning and working memory. Composite scores for overall cognition were calculated. Bivariate analyses indicated that handgrip strength and gait speed were positively associated with cognitive function. After accounting for confounders, positive associations between individual muscle (or physical) measures and cognitive performance were sustained for handgrip strength and psychomotor function, gait speed and psychomotor function, gait speed and attention, handgrip strength and overall cognition, and gait speed and overall cognition. In multivariable models, handgrip strength and gait speed independently predicted psychomotor function and overall cognition. No associations were detected between lean mass and cognition after adjusting for confounders. Thus, low muscle strength and slower gait speed, rather than low lean mass, were associated with poor cognition in older men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.