ArticleScientific reports2020
Estimation of homeostatic dysregulation and frailty using biomarker variability: a principal component analysis of hemodialysis patients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pre-Frailty and Frailty in Dialysis and Pre-Dialysis Patients: A Systematic Review of Clinical and Biochemical Markers.International journal of environmental research and public health · 2021Pooled it
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- Prognostic Value of Different Biological Age Estimation Methods in Breast Cancer Patients: A Population-Based Cohort Study Using NHANES 1999-2020.Health science reports · 2026Article
- Associations Between Polybrominated Diphenyl Ethers and Biological Aging in NHANES 2005-2010 and 2015-2016.GeoHealth · 2026Article
- Article
- Genetic association of proinflammatory cytokines in the pathogenesis of frailty syndrome: an application of ordinal logistic regression model.BMC geriatrics · 2025Article
- The association between dietary iron intake and the incidence of cardiometabolic multimorbidity: the mediating role of biological age.BMC public health · 2025Article
- Association between aging phenotypes and chronic kidney disease: evidence from the NHANES and Mendelian randomization.International urology and nephrology · 2025Article
- Intrinsic health as a foundation for a science of health.Science advances · 2025Review
- Influence of Frailty on Health-Related Quality of Life Trajectories in Chronic Kidney Disease Patients in India.Journal of clinical medicine · 2025Article
- The mediating role of biological age in the association between dietary index for gut microbiota and sarcopenia.Frontiers in immunology · 2025Article
- Associations of healthy eating patterns with biological aging: national health and nutrition examination survey (NHANES) 1999-2018.Nutrition journal · 2024Article
- Associations of daily eating frequency and nighttime fasting duration with biological aging in National Health and Nutrition Examination Survey (NHANES) 2003-2010 and 2015-2018.The international journal of behavioral nutrition and physical activity · 2024Article
- U-shaped association between sleep duration and biological aging: Evidence from the UK Biobank study.Aging cell · 2024Article
- Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems.Frontiers in aging · 2024Article
- Visit-to-visit variability in multiple biological measurements and cognitive performance and risk of cardiovascular disease: A cohort study.Cerebral circulation - cognition and behavior · 2024Article
- Application of early warning signs to physiological contexts: a comparison of multivariate indices in patients on long-term hemodialysis.Frontiers in network physiology · 2024Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Efficient representations of binarized health deficit data: the frailty index and beyond.GeroScience · 2023Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Increased intraindividual variability in several biological parameters is associated with aspects of frailty and may reflect impaired physiological regulation. As frailty involves a cumulative decline in multiple physiological systems, we aimed to estimate the overall regulatory capacity by applying a principal component analysis to such variability. The variability of 20 blood-based parameters was evaluated as the log-transformed coefficient of variation (LCV) for one year's worth of data from 580 hemodialysis patients. All the LCVs were positively correlated with each other and shared common characteristics. In a principal component analysis of 19 LCVs, the first principal component (PC1) explained 27.7% of the total variance, and the PC1 score exhibited consistent correlations with diverse negative health indicators, including diabetes, hypoalbuminemia, hyponatremia, and relative hypocreatininemia. The relationship between the PC1 score and frailty was subsequently examined in a subset of the subjects. The PC1 score was associated with the prevalence of frailty and was an independent predictor for frailty (odds ratio per SD: 2.31, P = 0.01) using a multivariate logistic regression model, which showed good discrimination (c-statistic: 0.85). Therefore, the PC1 score represents principal information shared by biomarker variabilities and is a reasonable measure of homeostatic dysregulation and frailty.
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