Evidence map›Paper›PMID 32587250›Full record

ArticleNature communications2020

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea.

Philippe Jean, Tommi Anttonen, Susann Michanski, Antonio M G de Diego, Anna M Steyer, Andreas Neef, David Oestreicher, Jana Kroll, Christos Nardis, Tina Pangršič and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Philippe Jean *Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5325-1370
Tommi Anttonen *Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.
Susann MichanskiCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.
Antonio M G de DiegoUCL Ear Institute and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Anna M SteyerElectron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Andreas NeefNeurophysics laboratory, Campus Institute for Dynamics of Biological Networks, University of Göttingen, Göttingen, Germany.
David OestreicherExperimental Otology Group, Institute for Auditory Neuroscience, InnerEarLab, and Department of Otolaryngology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-4541-6398
Jana KrollCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-4243-4088
Christos NardisElectron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Tina PangršičCollaborative Research Center 889, University of Göttingen, Göttingen, Germany.
Wiebke MöbiusElectron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID http://orcid.org/0000-0002-2902-7165
Jonathan AshmoreUCL Ear Institute and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID http://orcid.org/0000-0001-6522-3692
Carolin WichmannCollaborative Research Center 889, University of Göttingen, Göttingen, Germany. carolin.wichmann@med.uni-goettingen.de.
Tobias MoserInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany. tmoser@gwdg.de.ORCID http://orcid.org/0000-0001-7145-0533
Universitätsmedizin Göttingen · DENanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 · DEUniversity College London · GBGesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen · DEUniversity of Göttingen · DE

Funding

Wellcome Trust
6 · The paper itself

Abstract

Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 30% of the IHCs are electrochemically coupled in 'mini-syncytia'. This coupling permits transfer of fluorescently-labeled metabolites and macromolecular tracers. The membrane capacitance, Ca

Indexed as

CochleaHair Cells, Auditory, InnerAnimalsCalcium SignalingCochlear NerveElectron Microscope TomographyGiant CellsHearingMicePatch-Clamp TechniquesRodentiaSynapses

Identifiers

PMID32587250
PMCPMC7316811
OpenAlexW3037758634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.