Evidence map›Paper›PMID 32587179›Full record

ArticleIndian journal of ophthalmology2020

Glycerol-preserved corneal tissue in emergency corneal transplantation: An alternative for fresh corneal tissue in COVID-19 crisis.

Neeti Gupta, Renu Dhasmana, Amit Maitreya, Harsh Badahur

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Neeti GuptaDepartment of Ophthalmology, All India Institute of Medical Science, Rishikesh, Uttarakhand; Swami Ram Himalayan University, Jolly Grant, Doiwala, Dehradun, India.
Renu DhasmanaDepartment of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Ram Himalayan University, Jolly Grant, Doiwala, Dehradun, India.
Amit MaitreyaDepartment of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Ram Himalayan University, Jolly Grant, Doiwala, Dehradun, India.
Harsh BadahurDepartment of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Ram Himalayan University, Jolly Grant, Doiwala, Dehradun, India.
Himalayan University · INAll India Institute of Medical Sciences Rishikesh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDue to the COVID-19 pandemic, most of the eye banks have limited/stopped corneal collection, as this is a highly contagious disease. This has led to shortage of donor corneas worldwide. Glycerol preservation of tissue remains a viable option in this scenario. The objective is to compare fresh corneal tissue (FCT) with glycerol-preserved cornea (GPC) in emergency corneal transplantation.

methodsThis was a retrospective cohort study conducted in a tertiary care centre of Uttarakhand. Medical records of the patients who underwent therapeutic penetrating keratoplasty (TPK) were reviewed. FCT group included patients who underwent TPK with fresh corneal tissue and GPC group included patients who underwent TPK with glycerol preserved cornea. The indications and outcomes of TPK in the terms of therapeutic success were analysed and compared between both the groups.

resultsA total of 94 eyes of 91 patients underwent TPK from October 2011 to August 2017. FCT group included 60 eyes of 57 patients and GPC group included 34 eyes of 34 patients. The primary indication of TPK was infectious keratitis in both the groups (FCT-81.6%; GPC - 91.2%) There was no significant difference in the therapeutic success in both the groups (P = 0.741, Odds ratio- 1.59 with 95% CI- 0.39-6.44). Complications included glaucoma (FCT-21.7%; GPC- 35.2%) graft infection (FCT- 18.33% GPC- 2.9%); graft rejection (FCT-11.66%, GPC- 0%); and graft failure (FCT-88.33%, GPC-100%).

conclusionThe GPC is comparable to FCTs in therapeutic transplant and can be a useful interim procedure in saving the eyes in cases of infective keratitis in the time of crisis.

Indexed as

BetacoronavirusEmergenciesTissue DonorsCorneal DiseasesCorneal TransplantationCoronavirus InfectionsCOVID-19Cryoprotective AgentsFemaleFollow-Up StudiesGlycerolGraft SurvivalHumansMaleMiddle AgedPandemicsCryoprotective AgentsGlycerolCorneal transplantfresh corneal tissueglycerol-preserved corneakeratitistherapeutic keratoplasty

Identifiers

PMID32587179
PMCPMC7574125
OpenAlexW3037415258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.