Evidence map›Paper›PMID 32587133›Full record

ArticleInternational journal of stem cells2020

Adipose Tissue-Derived Stem Cells from Type 2 Diabetics Reveal Conservative Alterations in Multidimensional Characteristics.

Le Wang, Leisheng Zhang, Xue Liang, Jiaqi Zou, Na Liu, Tengli Liu, Guanqiao Wang, Xuejie Ding, Yaojuan Liu, Boya Zhang and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Le WangOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Leisheng ZhangThe Postdoctoral Research Station, School of Medicine, Nankai University, Tianjin, China.
Xue LiangNHC Key Laboratory for Critical Care Medicine, Tianjin, China.
Jiaqi ZouOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Na LiuNHC Key Laboratory for Critical Care Medicine, Tianjin, China.
Tengli LiuNHC Key Laboratory for Critical Care Medicine, Tianjin, China.
Guanqiao WangNHC Key Laboratory for Critical Care Medicine, Tianjin, China.
Xuejie DingOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Yaojuan LiuOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Boya ZhangOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Rui LiangOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Shusen WangOrgan Transplant Center, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Tianjin First Center Hospital · CNNankai University · CNTianjin Medical University · CNShanghai Clinical Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesAdipose tissue-derived mesenchymal stem cells (ASCs) are recognized as an advantaged source for the prevention and treatment of diverse diseases including type 2 diabetes mellitus (T2DM). However, alterations in characteristics of ASCs from the aforementioned T2DM patients are still obscure, which also hinder the rigorous and systematic illumination of progression and pathogenesis. METHODS AND

resultsIn this study, we originally isolated peripancreatic adipose tissue-derived mesenchymal stem cells from both human type 2 diabetic and non-diabetic donors (T2DM-ASCs, ND-ASCs) with the parental consent, respectively. We noticed that T2DM-ASCs exhibited indistinguishable immunophenotype, cell vitality, chondrogenic differentiation and stemness as ND-ASCs. Simultaneously, there's merely alterations in migration and immunoregulatory capacities in T2DM-ASCs. However, differing from ND-ASCs, T2DM-ASCs exhibited deficiency in adipogenic and osteogenic differentiation, and in particular, the delayed cell cycle and different cytokine expression spectrum.

conclusionsThe conservative alterations of T2DM-ASCs in multifaceted characteristics indicated the possibility of autologous application of ASCs for cell-based T2DM treatment in the future.

Indexed as

Adipose tissue-derived mesenchymal stem cellsCell vitalityImmunoregulationType 2 diabetes mellitus

Identifiers

PMID32587133
PMCPMC7378902
OpenAlexW3037885573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.