ArticleScience (New York, N.Y.)2020
Flexible recruitment of memory-based choice representations by the human medial frontal cortex.
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- Insights into the neural mechanisms supporting cognitive stability and flexibility from human intracranial electroencephalography.Neuroscience and biobehavioral reviews · 2026Review
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Decoding and Characterizing the Intracranial Representation of Semantic Information.bioRxiv : the preprint server for biology · 2026Article
- A communication subspace relays context-dependent actions from human prefrontal to motor cortex.Nature neuroscience · 2026Article
- Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance.The journal of headache and pain · 2026Article
- Computational neural dynamics of goal-directed visual attention in macaques.Science advances · 2026Article
- The cost of efficiency in flexible neural representations.bioRxiv : the preprint server for biology · 2026Article
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- Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation.Nature neuroscience · 2025Article
- Reusable modular architecture enables flexible cognitive operations.Research square · 2025Article
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- Reading specific memories from human neurons before and after sleep.bioRxiv : the preprint server for biology · 2025Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans.Cell reports · 2025Article
- Morphologic characteristics of distal intracranial arteries in relation to structural changes in the brain after chronic alcohol consumption.Scientific reports · 2025Article
- Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.bioRxiv : the preprint server for biology · 2025Article
- Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory-based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. These findings reveal a mechanism for flexibly and selectively engaging memory retrieval and show that memory-based choices are preferentially represented in the frontal cortex when required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.