Evidence map›Paper›PMID 32586348›Full record

ArticleTrials2020

Postoperative analgesia of scalp nerve block with ropivacaine in pediatric craniotomy patients: a protocol for a prospective, randomized, placebo-controlled, double-blinded trial.

Wei Xiong, Lu Li, Di Bao, Yaxin Wang, Yi Liang, Pengwei Lu, Di Zhang, Gaifen Liu, Lanxin Qiao, Na Zheng and 1 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Postcraniotomy Headache: Etiologies and Treatments.Current pain and headache reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wei XiongDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Lu LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Di BaoDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yaxin WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yi LiangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Pengwei LuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Di ZhangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Gaifen LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Lanxin QiaoDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Na ZhengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xu JinDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. jxsys2020@gmail.com.ORCID http://orcid.org/0000-0001-5944-0930
Capital Medical University · CN

Funding

Beijing municipal hospital scientific research training program PX2017011
6 · The paper itself

Abstract

backgroundModerate-to-severe postoperative pain following craniotomy has a high incidence in pediatric patients. Such pain may cause agitation, intracranial hypertension, epileptic seizures, and postoperative hematoma, which affect morbidity and mortality. Although scalp nerve block (SNB) achieves satisfactory pain relief except for suboccipital mid-craniotomy in adults and ropivacaine is widely used as a long-acting peripheral nerve block agent in children, there are few studies of SNB with ropivacaine in pediatric patients undergoing craniotomy. In addition, the neurosurgery operation time is relatively long, but the duration of action of SNB is limited. It is generally believed that postoperative SNB is better than preoperative SNB for postoperative analgesia. However, considering the concept of preemptive analgesia, we believe that preoperative SNB may achieve a longer postoperative analgesia effect than we expected.

methodsThis trial is a single-institution, prospective, randomized, controlled, double-blind study. A total of 180 children aged between 1 and 12 years who are undergoing elective craniotomy will be randomly allocated in a 1:1:1 ratio to three groups: group B (preoperative ropivacaine block group), group A (postoperative ropivacaine block group), and group N (nonblocking control group). This randomization will be stratified by age in two strata (1-6 years and 7-12 years). The primary outcome is the total consumption of sufentanil within 24 h after surgery. The secondary outcomes include assessment of pain scores, total consumption of sufentanil and emergency-remedy medicine consumption at observation points, the occurrence of postoperative complications, and the length of hospitalization after surgery. DISCUSSION: This study is designed to explore the effect and feasibility of SNB with ropivacaine for postoperative analgesia in pediatric patients undergoing craniotomy. Further aims are to compare the effects of preoperative and postoperative SNB on postoperative analgesia in order to identify whether there is a preemptive analgesic effect and determine the better time to implement SNB in pediatric patients during craniotomy.

trial registrationChinese Clinical Trial Registry ChiCTR1800017386. Registered on 27 July 2018.

Indexed as

Anesthetics, LocalChildChinaCraniotomyDouble-Blind MethodHumansNerve BlockPain ManagementPain MeasurementPostoperative PainPreoperative CareProspective StudiesRandomized Controlled Trials as TopicRopivacaineScalpSufentanilAnesthetics, LocalRopivacaineSufentanilChildrenCraniotomyPostoperative analgesiaProtocolRCTRopivacaineScalp nerve block

Identifiers

PMID32586348
PMCPMC7318534
OpenAlexW3037561866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.