Evidence map›Paper›PMID 32586263›Full record

ArticleThe journal of physiological sciences : JPS2020

Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation.

Toru Kawada, Yohsuke Hayama, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Tetsuo Tanaka, Minako Uenohara, Masaru Sugimachi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Effects of bilateral renal denervation on open-loop baroreflex function and urine excretion in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Toru KawadaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan. torukawa@ncvc.go.jp.ORCID http://orcid.org/0000-0002-4429-1802
Yohsuke HayamaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Takuya NishikawaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Satoru SueharaCorporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.
Satoshi SawadaCorporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.
Tetsuo TanakaCorporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.
Minako UenoharaCorporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.
Masaru SugimachiDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.

Funding

Japan Society for the Promotion of Science 18K06451Japan Society for the Promotion of Science (JP) 18K10695Salt Science Research Foundation 1921
6 · The paper itself

Abstract

Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic effect via the renal innervation and pressure diuresis. We examined whether PASA would reduce urine output regardless of the AP elevation. We also examined the impact of renal denervation (RDN) on urine output during PASA. The experiment was performed on rats 3 to 9 days after unilateral RDN (n = 10). Under anesthesia, systemic sympathetic nerve activity (SNA) was varied over a wide range via the carotid sinus baroreflex. The slope of urine flow versus SNA was positive (0.252 ± 0.052 μL·min

Indexed as

AnimalsArterial PressureBaroreflexBlood PressureDenervationKidneyMaleRatsRats, Inbred WKYSympathetic Nervous SystemUrinationArterial pressureEquilibrium diagramOpen-loop analysisPressure diuresisSympathetic nerve activity

Identifiers

PMID32586263
PMCPMC10717872

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.