Evidence map›Paper›PMID 32586195›Full record

ArticleGut microbes2020

The autoimmune susceptibility gene,

Ali Shawki, Rocio Ramirez, Marianne R Spalinger, Paul M Ruegger, Anica Sayoc-Becerra, Alina N Santos, Pritha Chatterjee, Vinicius Canale, Jonathan D Mitchell, John C Macbeth and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. TheGut microbes · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Interactions of pathogenicFrontiers in immunology · 2023
    Review
  8. Ptpn2: A Critical Regulator of Paneth Cell Homeostasis.Cellular and molecular gastroenterology and hepatology · 2023
    Article
  9. Role of adherent invasiveWorld journal of clinical cases · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Ali ShawkiDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.ORCID 0000-0002-6413-5313
Rocio RamirezDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.
Marianne R SpalingerDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.
Paul M RueggerDepartment of Microbiology and Plant Pathology, University of California Riverside , Riverside, California, USA.
Anica Sayoc-BecerraDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.
Alina N SantosDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.ORCID 0000-0002-9041-7250
Pritha ChatterjeeDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.
Vinicius CanaleDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.ORCID 0000-0002-2030-0268
Jonathan D MitchellDepartment of Microbiology and Plant Pathology, University of California Riverside , Riverside, California, USA.
John C MacbethDepartment of Microbiology and Plant Pathology, University of California Riverside , Riverside, California, USA.
Casey M GriesDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.
Michel L TremblayDepartment of Biochemistry, McGill University , Montreal, Quebec, Canada.ORCID 0000-0002-0281-541X
Ansel HsiaoDepartment of Microbiology and Plant Pathology, University of California Riverside , Riverside, California, USA.
James BornemanDepartment of Microbiology and Plant Pathology, University of California Riverside , Riverside, California, USA.
Declan F McColeDivision of Biomedical Sciences, University of California Riverside , Riverside, California, USA.ORCID 0000-0002-6286-0802
University of California, Riverside · USMcGill University · CA

Funding

A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
NIDDK NIH HHS R01 DK091281NIGMS NIH HHS R35 GM124724
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (

Indexed as

Bacterial AdhesionAnimalsEscherichia coliEscherichia coli InfectionsFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseHumansInflammatory Bowel DiseasesMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutProtein Tyrosine Phosphatase, Non-Receptor Type 2Protein Tyrosine Phosphatase, Non-Receptor Type 2Ptpn2 protein, mouseAIECCaco-2colitisepithelialinflammatory bowel diseaseLF82macrophagemicrobiome

Identifiers

PMID32586195
PMCPMC7524159
OpenAlexW3037405765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.