Evidence map›Paper›PMID 32586165›Full record

ArticleThe Journal of international medical research2020

Loss of death-associated protein kinase 1 in human bone marrow mesenchymal stem cells decreases immunosuppression of CD4+ T cells.

Shan Wang, Hongjun Su, Pei Feng, Wen Deng, Chunyan Su, Yanfeng Wu, Huiyong Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shan WangBiotherapy Center, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Hongjun SuCenter for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Pei FengCenter for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Wen DengCenter for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Chunyan SuMedical Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Yanfeng WuCenter for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Huiyong ShenBiotherapy Center, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.ORCID https://orcid.org/0000-0002-4317-3468
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the roles of human mesenchymal stem cell (hMSC) death-associated protein kinase 1 (DAPK1) in modulating CD4+ T lymphocyte proliferation.

methodsHuman MSCs and peripheral blood mononuclear cells were isolated and cocultured

resultsDAPK1 was abundantly expressed in

conclusionsThe DAPK1-IL-10 axis mediates a novel immunoregulatory function of hMSCs toward CD4+ T cells.

Indexed as

Mesenchymal Stem CellsCD4-Positive T-LymphocytesCell ProliferationCells, CulturedDeath-Associated Protein KinasesHumansImmunosuppression TherapyLeukocytes, MononuclearDeath-Associated Protein KinasesCD4+ T cellsdeath-associated protein kinase 1Human mesenchymal stem cellimmunomodulationinterleukin-10peripheral blood mononuclear cell

Identifiers

PMID32586165
PMCPMC7323303
OpenAlexW3038098857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.