Evidence map›Paper›PMID 32586060›Full record

ArticleInternational journal of molecular sciences2020

Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of

Sylwester Ślusarczyk, F Sezer Senol Deniz, Renata Abel, Łukasz Pecio, Horacio Pérez-Sánchez, José P Cerón-Carrasco, Helena den-Haan, Priyanka Banerjee, Robert Preissner, Edward Krzyżak and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. From Metabolites to Mechanisms:Food science & nutrition · 2026
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  5. Evaluation ofMolecules (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Sylwester ŚlusarczykDepartment of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50556 Wroclaw, Poland.ORCID 0000-0003-2722-0890
F Sezer Senol DenizDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.ORCID 0000-0002-5850-9841
Renata AbelDepartment of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50556 Wroclaw, Poland.ORCID 0000-0003-0802-8078
Łukasz PecioDepartment of Biochemistry and Crop Quality, IUNG-Institute of Soil Science and Plant Cultivation, 24100 Puławy, Poland.ORCID 0000-0002-7407-6716
Horacio Pérez-SánchezStructural Bioinformatics and High Performance Computing Research Group, Universidad Católica San Antonio de Murcia (UCAM), 30107, Murcia, Spain.ORCID 0000-0003-4468-7898
José P Cerón-CarrascoReconocimiento y Encapsulación Molecular (REM), Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, Spain.ORCID 0000-0003-0668-9227
Helena den-HaanStructural Bioinformatics and High Performance Computing Research Group, Universidad Católica San Antonio de Murcia (UCAM), 30107, Murcia, Spain.
Priyanka BanerjeeStructural Bioinformatics Group, Institute for Physiology & ECRC, Charité University Medicine, 10115 Berlin, Germany.
Robert PreissnerStructural Bioinformatics Group, Institute for Physiology & ECRC, Charité University Medicine, 10115 Berlin, Germany.
Edward KrzyżakDepartment of Inorganic Chemistry, Wroclaw Medical University, 50556 Wroclaw, Poland.ORCID 0000-0002-5000-2448
Wiesław OleszekDepartment of Biochemistry and Crop Quality, IUNG-Institute of Soil Science and Plant Cultivation, 24100 Puławy, Poland.ORCID 0000-0002-4189-6603
Ilkay E OrhanDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.ORCID 0000-0002-7379-5436
Adam MatkowskiDepartment of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50556 Wroclaw, Poland.
Wroclaw Medical University · PLUniversidad Católica de Murcia · ESCharité - Universitätsmedizin Berlin · DEGazi University · TRInstitute of Soil Science and Plant Cultivation · PL

Funding

Fundación Séneca del Centro de Coordinación de la Investigación de la Región de Murcia 20988/PI/18 and 20524/PDC/18Ministerio de Ciencia e Innovación CTQ2017-87974-RMinisterstwo Nauki i Szkolnictwa Wyższego 96/E-394/SPUB/2019Narodowe Centrum Nauki FUGA 2014/12/S/NZ9/00715Türkiye Bilimsel ve Teknolojik Araştirma Kurumu POLTUR/PLANT-ALZH/5/2015Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu SUB.D033.19.009
6 · The paper itself

Abstract

Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids from

Indexed as

AcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsDiterpenesHumansLamiaceaeMolecular Docking SimulationPlant ExtractsPlant RootsStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsDiterpenesPlant Extractscholinesterasesmolecular dockingstructure elucidationtanshinones

Identifiers

PMID32586060
PMCPMC7352922
OpenAlexW3036483501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.