Evidence map›Paper›PMID 32586031›Full record

ArticleInternational journal of molecular sciences2020

SpeS: A Novel Superantigen and Its Potential as a Vaccine Adjuvant against Strangles.

C Coral Dominguez-Medina, Nicola L Rash, Sylvain Robillard, Carl Robinson, Androulla Efstratiou, Karen Broughton, Julian Parkhill, Matthew T G Holden, Maria R Lopez-Alvarez, Romain Paillot and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

C Coral Dominguez-MedinaAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.
Nicola L RashAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.
Sylvain RobillardAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.
Carl RobinsonAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.
Androulla EfstratiouPublic Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
Karen BroughtonPublic Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
Julian ParkhillWellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.ORCID 0000-0002-7069-5958
Matthew T G HoldenWellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
Maria R Lopez-AlvarezAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.ORCID 0000-0003-4207-0739
Romain PaillotAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.ORCID 0000-0003-3081-2037
Andrew S WallerAnimal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, UK.
Animal Health Trust · GBPublic Health England · GBUniversity of Cambridge · GBUniversity of St Andrews · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P002757/1
6 · The paper itself

Abstract

Bacterial superantigens (sAgs) are powerful activators of the immune response that trigger unspecific T cell responses accompanied by the release of proinflammatory cytokines.

Indexed as

Adjuvants, ImmunologicAntigen PresentationBacterial ProteinsExotoxinsHistocompatibility Antigens Class IIHumansMembrane ProteinsMeningitisPhylogenyReceptors, Antigen, T-CellStreptococcal InfectionsStreptococcus equiSuperantigensVaccinesAdjuvants, ImmunologicBacterial ProteinsExotoxinsHistocompatibility Antigens Class IIMembrane ProteinsReceptors, Antigen, T-CellSpeA protein, Streptococcus pyogenesSuperantigensVaccinesadjuvanthorseimmune responsestranglesStreptococcus equiStreptococcus zooepidemicussuperantigenvaccine

Identifiers

PMID32586031
PMCPMC7352279
OpenAlexW3036587109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.