ReviewInternational journal of molecular sciences2020
Tooth Enamel and its Dynamic Protein Matrix.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 110 citations in OpenAlex.
- Article
- Mapping a differentiation architecture for hard tissue mineralization with large-scale single-cell atlases.PLoS computational biology · 2026Article
- Melatonin Rescues Enamel Defects Induced by Maternal Circadian Disruption via Targeting the BMAL1-JNK3 Axis.International dental journal · 2026Article
- Deproteinization-Induced Deterioration of the Mechanical and Tribological Behaviors of Mature Giant Panda Enamel.Animals : an open access journal from MDPI · 2026Article
- Human Enamel Formation: A Scoping Review for Oral Health Professionals.Dentistry journal · 2026Review
- Article
- Remineralizing and Antimicrobial Effects of a Chitosan-Xylitol Hydrogel on Dental Enamel: An In Vitro Study.Gels (Basel, Switzerland) · 2026Article
- The relationship between nutrition, diet, and early childhood caries: A cross-sectional study using 2009 to 2014 NHANES data.Medicine · 2026Article
- Application of Polymers in Advanced Materials for Enamel and Dentine Remineralization.ACS biomaterials science & engineering · 2026Review
- Impact of Secondhand Smoke on the Biomineralization of Dental Enamel in Rats.Calcified tissue international · 2026Article
- Proteomic Signatures of Dental Enamel Hypomineralization: Divergent Molecular Pathways in Coal-Burning vs. Drinking-Water Fluorosis.Biological trace element research · 2026Article
- Natural Bioactive Compounds in Dental Materials: Balancing Biological Activity and Functional Properties.Pharmaceutics · 2026Review
- Reduced Dietary Protein Induces Changes in the Dental Proteome.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Amelogenin enhances the reparative competence of trauma-affected periodontal ligament stem cells: implications for tooth autotransplantation.BMC oral health · 2026Article
- Effect of different dilution levels of toothpastes on the abrasive wear on enamel and dentin in in-vitro studies.Scientific reports · 2026Article
- The Interplay of Immune Response and Dental Enamel Formation in Health and Sickness.Advances in experimental medicine and biology · 2026Review
- Dental fluorosis in the European roe deer (Capreolus capreolus): A review of the pathological changes in the enamel of fluorotic cheek teeth and the abnormal pattern of dental wear in affected dentitions.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- Antimicrobial peptides derived from human ameloblastin targeting biofilms.BMC oral health · 2025Article
- From Biomechanics to Bioinnovation: Emerging Applications of Piezoelectric Materials and Phenomena in Dentistry.Biomedicines · 2025Review
- Relationship of finger dermatoglyphics with ameloglyphics and their values as dental caries predictors in primary teeth.BMC oral health · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tooth enamel is the outer covering of tooth crowns, the hardest material in the mammalian body, yet fracture resistant. The extremely high content of 95 wt% calcium phosphate in healthy adult teeth is achieved through mineralization of a proteinaceous matrix that changes in abundance and composition. Enamel-specific proteins and proteases are known to be critical for proper enamel formation. Recent proteomics analyses revealed many other proteins with their roles in enamel formation yet to be unraveled. Although the exact protein composition of healthy tooth enamel is still unknown, it is apparent that compromised enamel deviates in amount and composition of its organic material. Why these differences affect both the mineralization process before tooth eruption and the properties of erupted teeth will become apparent as proteomics protocols are adjusted to the variability between species, tooth size, sample size and ephemeral organic content of forming teeth. This review summarizes the current knowledge and published proteomics data of healthy and diseased tooth enamel, including advancements in forensic applications and disease models in animals. A summary and discussion of the status quo highlights how recent proteomics findings advance our understating of the complexity and temporal changes of extracellular matrix composition during tooth enamel formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.