Evidence map›Paper›PMID 32585871›Full record

ArticleInternational journal of molecular sciences2020

Maackiain Ameliorates 6-Hydroxydopamine and

Rong-Tzong Tsai, Chia-Wen Tsai, Shih-Ping Liu, Jia-Xin Gao, Yun-Hua Kuo, Pei-Min Chao, Huey-Shan Hung, Woei-Cherng Shyu, Shinn-Zong Lin, Ru-Huei Fu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. APurinergic signalling · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Maackiain Mimics Caloric Restriction throughInternational journal of molecular sciences · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Polyphenolic Compounds fromAntioxidants (Basel, Switzerland) · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Autophagy and apoptosis cascade: which is more prominent in neuronal death?Cellular and molecular life sciences : CMLS · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Rong-Tzong TsaiInstitute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan.
Chia-Wen TsaiDepartment of Nutrition, China Medical University, Taichung 40402, Taiwan.
Shih-Ping LiuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Jia-Xin GaoGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Yun-Hua KuoDepartment of Nursing, Taipei Veterans General Hospital, Taipei 12217, Taiwan.
Pei-Min ChaoDepartment of Nutrition, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-4846-3245
Huey-Shan HungGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Woei-Cherng ShyuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Shinn-Zong LinDepartment of Neurosurgery, Bioinnovation Center, Tzu Chi foundation, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Ru-Huei FuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
China Medical University · TWAsia University · TWChung Shan Medical University · TWTaipei Veterans General Hospital · TWTzu Chi University · TW

Funding

China Medical University Hospital DMR107-106Ministry of Science and Technology (Taiwan) MOST 105-2314-B-039 -017-MY3
6 · The paper itself

Abstract

The movement disorder Parkinson's disease (PD) is the second most frequently diagnosed neurodegenerative disease, and is associated with aging, the environment, and genetic factors. The intracellular aggregation of α-synuclein and the loss of dopaminergic neurons in the substantia nigra pars compacta are the pathological hallmark of PD. At present, there is no successful treatment for PD. Maackiain (MK) is a flavonoid extracted from dried roots of

Indexed as

Adrenergic Agentsalpha-SynucleinAnimalsApoptosisAutophagyCaenorhabditis elegansDisease Models, AnimalGene Expression RegulationHumansNeuroblastomaOxidopamineParkinson DiseasePhytoalexinsProtein KinasesPTEN-Induced Putative KinasePterocarpansAdrenergic Agentsalpha-SynucleininerminOxidopamineparkin proteinPhytoalexinsProtein KinasesPTEN-Induced Putative KinasePterocarpansUbiquitin-Protein Ligases6-HydroxydopamineapoptosisautophagyCaenorhabditis elegansmaackiainparkinParkinson’s diseaseproteasomeSH-SY5Y cellα-Synuclein

Identifiers

PMID32585871
PMCPMC7352553
OpenAlexW3036219220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.