ReviewNutrients2020
Role of Minerals and Trace Elements in Diabetes and Insulin Resistance.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07711587 (A Pilot Study Investigating the Effects of Diaplex Supplementation on Glucose Regulation in Otherwise Healthy Adults With Elevated Blood Glucose Levels), which is not on this map. Cited by 159 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study Investigating the Effects of Diaplex Supplementation on Glucose Regulation in Otherwise Healthy Adults With Elevated Blood Glucose Levels
Who cites it
159 citing papers in PubMed, 4 syntheses or guidelines pooled it, 388 citations in OpenAlex.
- Serum Selenium Levels and Lipid Profile: A Systematic Review and Meta-analysis of Observational Studies.Biological trace element research · 2025Pooled it
- An evidence-based assessment of the nutritional recommendations for the prevention of diabetes mellitus.Hormones (Athens, Greece) · 2025Pooled it
- The crucial role and mechanism of insulin resistance in metabolic disease.Frontiers in endocrinology · 2023Pooled it
- Associations of Glycemic Index and Glycemic Load with Cardiovascular Disease: Updated Evidence from Meta-analysis and Cohort Studies.Current cardiology reports · 2022Pooled it
- A comparative study to assess the use of chromium in type 2 diabetes mellitus.Journal of medicine and life · 2023Trial
- Interrelationship between micronutrients and cardiovascular structure and function in type 2 diabetes.Journal of nutritional science · 2021Trial
- Modulatory Effects of Essential Trace Elements on Glycemic Biomarkers in Toxic Metal-Induced Associated Diabetes.Biological trace element research · 2026Article
- Mechanistic Insights Into Wall-Breaking Selenium-Enriched Yeast Intervention on Glycolipid Homeostasis in Type 2 Diabetic Rats Through Gut Microbiota Modulation.Journal of food science · 2026Article
- Heavy Metal Air Pollution: Human Health Effects and Nanomaterial Strategies for Monitoring and Remediation.Biological trace element research · 2026Review
- TyG-BMI as a Marker of Metabolic Status and Its Association with Bone Quality and Mineral Metabolism: A Sex-Specific Analysis.Journal of clinical medicine · 2026Article
- Serum Levels of Trace Elements and Minerals in Non-alcoholic Fatty Liver Disease Patients with and without Type 2 Diabetes are Associated with Metabolic Risk Markers.Biological trace element research · 2026Article
- Effect of strategic supplementations of antioxidant multiminerals and vitamins to transitional buffaloes on serum biochemistry, non-esterified fatty acid and calf health.Tropical animal health and production · 2026Article
- High glucose diet induces hepatic iron overload contributing to metabolic dysfunction.iScience · 2026Article
- A conceptual framework integrating mechanisms linking nut consumption and energy balance.Frontiers in nutrition · 2026Review
- Zinc Deficiency Aggravates High-Fat Diet-Induced Renal Injury by Regulating Oxidative Stress and Inflammation via the Nrf2/HO-1 Pathway.Biological trace element research · 2026Article
- Is it possible for type 2 diabetic patients with low level of copper to have better glycemic control under different apolipoprotein B levels?Frontiers in endocrinology · 2026Article
- Screening of probiotics for promoting mineral absorption based onFrontiers in microbiology · 2026Article
- Accumulation characteristics of mineral elements in the fruiting bodies ofFrontiers in nutrition · 2026Article
- Loss of Fmr1 reorganizes the multi-elemental composition across tissues in Fragile X Syndrome mice.PloS one · 2026Article
- Investigating the protective effect of zinc supplementation on streptozotocin-induced pancreatic beta-cell damage via the HMGB1/TLR2/MAPK pathway.Iranian journal of basic medical sciences · 2026Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in these micronutrients are related to widespread human health problems. This review article is focused on some of these minerals and trace element deficiencies and their consequences in diabetes and insulin resistance. The levels of trace elements vary considerably among different populations, contingent on the composition of the diet. In several Asian countries, large proportions of the population are affected by a number of micronutrient deficiencies. Local differences in selenium, zinc, copper, iron, chromium and iodine in the diet occur in both developed and developing countries, largely due to malnutrition and dependence on indigenous nutrition. These overall deficiencies and, in a few cases, excess of essential trace elements may lead to imbalances in glucose homeostasis and insulin resistance. The most extensive problems affecting one billion people or more worldwide are associated with inadequate supply of a number of minerals and trace elements including iodine, selenium, zinc, calcium, chromium, cobalt, iron, boron and magnesium. This review comprises various randomized controlled trials, cohort and case-controlled studies, and observational and laboratory-based studies with substantial outcomes of micronutrient deficiencies on diabetes and insulin resistance in diverse racial inhabitants from parts of Asia, Africa, and North America. Changes in these micronutrient levels in the serum and urine of subjects may indicate the trajectory toward metabolic changes, oxidative stress and provide disease-relevant information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.