Evidence map›Paper›PMID 32585776›Full record

ArticleESC heart failure2020

Elevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township.

Tess E Peterson, Jason V Baker, Lye-Yeng Wong, Adam Rupert, Ntobeko A B Ntusi, Hanif Esmail, Robert Wilkinson, Irini Sereti, Graeme Meintjes, Mpiko Ntsekhe and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

Tess E PetersonDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Jason V BakerInfectious Diseases, Hennepin Healthcare Research Institute, Minneapolis, MN, USA.
Lye-Yeng WongDepartment of Surgery, Oregon Health Sciences University, Portland, OR, USA.
Adam RupertLeidos Biomedical Research Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Ntobeko A B NtusiDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Hanif EsmailWellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa.
Robert WilkinsonDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Irini SeretiLaboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Graeme MeintjesDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Mpiko NtsekheDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Friedrich ThienemannDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAHennepin Healthcare Research Institute · USLeidos (United States) · USMinnesota Department of Health · USNational Institutes of Health · USOregon Health & Science University · USThe Francis Crick Institute · GBUniversity College London · GBUniversity Hospital of Zurich · CH

Funding

Immunopathogenic Mechanisms of Human Immunodeficiency Virus (HIV) DiseaseZIAAI001121 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SERETI, IRINI · 2010 to 2025
$27.2M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
AerasBill & Melinda Gates FoundationEuropean & Developing Countries Clinical Trials Partnership IP.07.32080.002Hennepin Health ServicesNHLBI NIH HHS T32 HL007779Oxford-Emergent Tuberculosis ConsortiumWellcome Trust 095780Wellcome Trust 104-803Wellcome Trust 203135
6 · The paper itself

Abstract

aimsEfforts to improve access to antiretroviral therapy (ART) have shifted morbidity and mortality among persons living with HIV (PLWH) from AIDS to non-communicable diseases, such as cardiovascular disease (CVD). However, contemporary data on CVD among PLWH in sub-Saharan Africa in the current ART era are lacking. The aim of this study was to assess the burden of cardiac stress among PLWH in South Africa via measurement of N-terminal prohormone of brain natriuretic peptide (NT-proBNP). METHODS AND

resultsNT-proBNP was measured at baseline in 224 PLWH enrolled in a sub-study of a tuberculosis vaccine trial in Khayelitsha township near Cape Town, South Africa. Thresholds were applied at the assay's limit of detection (≥137 pg/mL) and a level indicative of symptomatic heart failure in the acute setting (>300 pg/mL). Mean (SD) age of participants was 39 (6) years, 86% were female, and 19% were hypertensive. Mean (SD) duration of HIV diagnosis was 8.3 (3.9) years and CD4 + count was 673 (267) with 79% prescribed ART for a duration of 5.6 (2.7) years. Thirty-one percent of participants had NT-proBNP > 300 pg/mL. Elevated vs. undetectable NT-proBNP level was associated with older age (P = 0.04), no ART (P = 0.03), and higher plasma tumour necrosis factor-α (P = 0.01).

conclusionsAmong South African PLWH largely free of known CVD and on ART with high CD4 + counts and few comorbidities, we observed a high proportion with elevated NT-proBNP levels, suggesting the burden of cardiac stress in this population may be high. This observation underscores the need for more in-depth research, including the current effect of HIV on heart failure risk among a growing ART-treated population in sub-Saharan Africa.

Indexed as

Cardiovascular DiseasesHIV InfectionsAdultAgedAnti-Retroviral AgentsFemaleHumansMaleNatriuretic Peptide, BrainPeptide FragmentsSouth AfricaAnti-Retroviral AgentsNatriuretic Peptide, BrainPeptide FragmentsCardiac stressHIV infectionNT-proBNPSouth Africa

Identifiers

PMID32585776
PMCPMC7524119
OpenAlexW3037051374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.