ArticleOsteoarthritis and cartilage2020
The relation of peripheral and central sensitization to muscle co-contraction: the MOST study.
Article in Osteoarthritis and cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Cognitive muscular therapy™ for knee osteoarthritis: A feasibility randomised controlled trial.Osteoarthritis and cartilage open · 2026Trial
- Excitation of the bottom-up pathways has no effect on remote muscle fatigue in healthy participants.Experimental brain research · 2024Trial
- Diagnostic Utility of Surface Electromyography for Identifying Muscles Affected by Myofascial Trigger Points: A Scoping Review.Biomedicines · 2026Review
- Prevalence and Multivariate Impact of Musculoskeletal Disorders on General Health, Occupational Fatigue, and Productivity in an Industrial Workforce.La Medicina del lavoro · 2026Article
- Bone marrow lesion coexisted with subchondral bone attrition and/or subchondral bone cyst is associated with knee pain in knee osteoarthritis regardless of cartilage lesion: the Bunkyo health study.Arthritis research & therapy · 2025Article
- Association of Knee Pain Frequency and Severity with Quadriceps Strength but Not Rate of Decline Over Four Years.ACR open rheumatology · 2025Article
- Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.Journal of orthopaedic surgery and research · 2025Review
- Muscle activation patterns and gait changes in unilateral knee osteoarthritis patients: a comparative study with healthy controls.Clinical rheumatology · 2024Article
- Relationship between Fear-Avoidance Beliefs and Muscle Co-Contraction in People with Knee Osteoarthritis.Sensors (Basel, Switzerland) · 2024Article
- Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST).Osteoarthritis and cartilage · 2024Observational
- Association of mechanical temporal summation of pain with muscle co-contraction during walking in people with knee osteoarthritis.Clinical biomechanics (Bristol, Avon) · 2023Article
- Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study.Osteoarthritis and cartilage · 2023Article
- Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study.Osteoarthritis and cartilage · 2023Article
- Fire Needling Therapy versus Manual Acupuncture in Post-Stroke Complex Regional Pain Syndrome of the Upper Limb: Study Protocol for a Pilot Randomised Controlled Trial.Journal of pain research · 2023Article
- Fire Needling Therapy of Different Frequencies versus External Diclofenac Diethylamine Emulgel for Knee Osteoarthritis: Study Protocol for a Pilot Randomized Controlled Trial.Journal of pain research · 2023Article
- Association between hamstring coactivation during isokinetic quadriceps strength testing and knee cartilage worsening over 24 months.Osteoarthritis and cartilage · 2022Article
- A new integrated behavioural intervention for knee osteoarthritis: development and pilot study.BMC musculoskeletal disorders · 2021Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo examine the relation of pain sensitization to altered motor activity in knee OA as assessed by hamstrings muscle co-contraction during maximal effort knee extension.
designMedial, lateral, and overall hamstring co-contraction was assessed in the Multicenter Osteoarthritis (MOST) Study cohort using electromyography during isokinetic knee extension at 60°/second. Mechanical temporal summation of pain (TS) was assessed at the right wrist and pressure pain thresholds (PPT) were assessed at the patellae; PPTs were categorized into sex-specific tertiles. Muscle co-contraction was categorized into age- and sex-specific tertiles. We evaluated the relation of measures of sensitization to muscle co-contraction using a generalized logistic regression model.
results1633 participants were included: mean age and BMI was 67.3 ± 7.7 years and 30.3 ± 5.6 kg/m
conclusionGreater pain sensitization, as assessed by presence of TS at the wrist and low patellar PPT, was associated with greater overall and medial hamstring co-contraction during knee extension. This provides support to the possibility that peripheral and/or central nervous system alterations may not only affect pain sensitivity, but also motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.