Evidence map›Paper›PMID 32585166›Full record

ArticleKidney international2020

Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study.

James T Grist, Frank Riemer, Esben S S Hansen, Rasmus S Tougaard, Mary A McLean, Joshua Kaggie, Nikolaj Bøgh, Martin J Graves, Ferdia A Gallagher, Christoffer Laustsen

Abstract readMulticenter Study
In one paragraph

Article in Kidney international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Redefining the concept of residual renal function with kidney sodium MRI: a pilot study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Observational
  7. Article
  8. Article
  9. QuantitativeMagma (New York, N.Y.) · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Clinically feasible BNMR in biomedicine · 2023
    Article
  15. RF coil design for accurate parallel imaging onMagnetic resonance in medicine · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James T GristDepartment of Radiology, University of Cambridge, Cambridge, UK.
Frank RiemerDepartment of Radiology, University of Cambridge, Cambridge, UK.
Esben S S HansenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Rasmus S TougaardMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Mary A McLeanDepartment of Radiology, University of Cambridge, Cambridge, UK; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK.
Joshua KaggieDepartment of Radiology, University of Cambridge, Cambridge, UK.
Nikolaj BøghMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Martin J GravesDepartment of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK. Electronic address: fag1000@cam.ac.uk.
Christoffer LaustsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Funding

Cancer Research UK 16628Cancer Research UK 27150Cancer Research UK C19212/A16628Cancer Research UK C8742/A18097Department of HealthMedical Research Council
6 · The paper itself

Abstract

Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements. Thus, rapid sodium MRI can be used to dynamically quantify sodium biodistribution in the porcine and human kidney.

Indexed as

KidneySodiumAnimalsDiuresisMagnetic Resonance ImagingSwineTissue DistributionSodiumMRIporcinerenalsodiumvolunteer

Identifiers

PMID32585166
PMCPMC7652549

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.