ArticleGenome biology and evolution2020
The Coevolution of Fungal Mitochondrial Introns and Their Homing Endonucleases (GIY-YIG and LAGLIDADG).
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 82 citations in OpenAlex.
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- Recurrent Modular Assembly Drives Independent Origins of Group II Introns Encoding LAGLIDADG Homing Endonucleases.Genome biology and evolution · 2026Article
- Characterization of Six Complete Mitochondrial Genomes and ITS Sequences fromInternational journal of molecular sciences · 2026Article
- Unraveling Mitochondrial Genome Evolution inJournal of fungi (Basel, Switzerland) · 2026Article
- Insights into the Phylogeny ofJournal of fungi (Basel, Switzerland) · 2026Article
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- Comparative Mitogenomics Reveals Intron Dynamics and Mitochondrial Gene Expression Shifts in Domesticated and WildJournal of fungi (Basel, Switzerland) · 2026Article
- Comparative mitogenomics of kingdom Fungi - evolutionary insights and metagenomic applications.Nucleic acids research · 2026Article
- Insights into intraspecific variation and genotyping ofIMA fungus · 2026Article
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- Complete mitochondrial genomic sequence ofMitochondrial DNA. Part B, Resources · 2026Article
- Evolutionary insights intoIMA fungus · 2026Article
- Comparative analysis of mitochondrial genomes in lycoperdaceae fungi reveals intron dynamics and phylogenetic relationships.BMC genomics · 2025Article
- Characterization and Phylogenetic Analysis of the Complete Mitogenomes ofJournal of fungi (Basel, Switzerland) · 2025Article
- An Alternative Self-Splicing Intron Lifecycle Revealed by Dynamic Intron Turnover in Epichloë Endophyte Mitochondrial Genomes.Molecular biology and evolution · 2025Article
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- Characterization of the mitochondrial genomes forIMA fungus · 2025Article
- Phylogenetic and evolutionary insights from 30 newly-assembledIMA fungus · 2025Article
- The six whole mitochondrial genomes for theIMA fungus · 2025Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal mitochondrial (mt) genomes exhibit great diversity in size which is partially attributed to their variable intergenic regions and most importantly to the inclusion of introns within their genes. These introns belong to group I or II, and both of them are self-splicing. The majority of them carry genes encoding homing endonucleases, either LAGLIDADG or GIY-YIG. In this study, it was found that these intronic homing endonucleases genes (HEGs) may originate from mt free-standing open reading frames which can be found nowadays in species belonging to Early Diverging Fungi as "living fossils." A total of 487 introns carrying HEGs which were located in the publicly available mt genomes of representative species belonging to orders from all fungal phyla was analyzed. Their distribution in the mt genes, their insertion target sequence, and the phylogenetic analyses of the HEGs showed that these introns along with their HEGs form a composite structure in which both selfish elements coevolved. The invasion of the ancestral free-standing HEGs in the introns occurred through a perpetual mechanism, called in this study as "aenaon" hypothesis. It is based on recombination, transpositions, and horizontal gene transfer events throughout evolution. HEGs phylogenetically clustered primarily according to their intron hosts and secondarily to the mt genes carrying the introns and their HEGs. The evolutionary models created revealed an "intron-early" evolution which was enriched by "intron-late" events through many different independent recombinational events which resulted from both vertical and horizontal gene transfers.
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