ArticlePloS one2020
Screening archaeological bone for palaeogenetic and palaeoproteomic studies.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 61 citations in OpenAlex.
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- Bone diagenesis and stratigraphic implications from Pleistocene karst systems.Scientific reports · 2025Article
- Clothomics: a practical guide to understand the opportunities and challenges of omics-based methods in archaeological cloth research.NPJ heritage science · 2025Review
- Cell-free DNA from nail clippings as source of normal control for genomic studies in hematologic malignancies.Haematologica · 2024Article
- Tracking of Infectious Diseases in Shahr-i Sokhta (Burnt City) during the Bronze Age (ca. 3200-2200 BCE) through Anemic Signs Observed in Excavated Human Skeletons.Iranian journal of public health · 2024Article
- Evaluation of a New DNA Extraction Method on Challenging Bone Samples Recovered from a WWII Mass Grave.Genes · 2024Article
- A fresh perspective on infrared spectroscopy as a prescreening method for molecular and stable isotopes analyses on ancient human bones.Scientific reports · 2024Article
- Comparison of DNA preservation and ATR-FTIR spectroscopy indices of cortical and trabecular bone of metacarpals and metatarsals.Scientific reports · 2023Article
- North and South: Exploring isotopic analysis of bone carbonates and collagen to understand post-medieval diets in London and northern England.American journal of biological anthropology · 2023Article
- On Roth's "human fossil" from Baradero, Buenos Aires Province, Argentina: morphological and genetic analysis.Swiss journal of palaeontology · 2023Article
- Biomolecular histology as a novel proxy for ancient DNA and protein sequence preservation.Ecology and evolution · 2022Article
- The genetic history of the Southern Arc: A bridge between West Asia and Europe.Science (New York, N.Y.) · 2022Article
- Isotope analysis of human dental calculus δRapid communications in mass spectrometry : RCM · 2022Article
- Review
- Combining elemental and immunochemical analyses to characterize diagenetic alteration patterns in ancient skeletal remains.Scientific reports · 2022Article
- Species identification of Australian marsupials using collagen fingerprinting.Royal Society open science · 2021Article
- Bone fragment or bone powder? ATR-FTIR spectroscopy-based comparison of chemical composition and DNA preservation of bones after 10 years in a freezer.International journal of legal medicine · 2021Article
- Proteome Variation with Collagen Yield in Ancient Bone.Journal of proteome research · 2021Article
- The bone-degrading enzyme machinery: From multi-component understanding to the treatment of residues from the meat industry.Computational and structural biotechnology journal · 2021Article
Corrections and comments
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Authors and funding
20 authors at 11 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recovery and analysis of ancient DNA and protein from archaeological bone is time-consuming and expensive to carry out, while it involves the partial or complete destruction of valuable or rare specimens. The fields of palaeogenetic and palaeoproteomic research would benefit greatly from techniques that can assess the molecular quality prior to sampling. To be relevant, such screening methods should be effective, minimally-destructive, and rapid. This study reports results based on spectroscopic (Fourier-transform infrared spectroscopy in attenuated total reflectance [FTIR-ATR]; n = 266), palaeoproteomic (collagen content; n = 226), and palaeogenetic (endogenous DNA content; n = 88) techniques. We establish thresholds for three different FTIR indices, a) the infrared splitting factor [IRSF] that assesses relative changes in bioapatite crystals' size and homogeneity; b) the carbonate-to-phosphate [C/P] ratio as a relative measure of carbonate content in bioapatite crystals; and c) the amide-to-phosphate ratio [Am/P] for assessing the relative organic content preserved in bone. These thresholds are both extremely reliable and easy to apply for the successful and rapid distinction between well- and poorly-preserved specimens. This is a milestone for choosing appropriate samples prior to genomic and collagen analyses, with important implications for biomolecular archaeology and palaeontology.
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