ArticleJoint diseases and related surgery2020
Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats.
Article in Joint diseases and related surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of hyperbaric oxygen therapy on bone, muscle, cartilage, tendon and ligaments in animal studies: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Effects of hyperbaric oxygen therapy on human musculoskeletal pathologies in clinical studies: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- The Effects of Irisin and Bevacizumab on Hyaline Cartilage Regeneration in Osteochondral Defects: An Experimental Study in Rats.Clinics in orthopedic surgery · 2025Article
- Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing.Journal of orthopaedic translation · 2025Article
- Hyperbaric Oxygen Therapy as a Renewed Hope for Ischemic Craniomaxillofacial Diseases.Healthcare (Basel, Switzerland) · 2025Review
- Effects of adipose tissue-derived stromal vascular fraction on osteochondral defects treated by hyaluronic acid-based scaffold: An experimental study.Joint diseases and related surgery · 2021Article
- Effect of cartilage thickness mismatch in osteochondral grafting from knee to talus on articular contact pressures: A finite element analysis.Joint diseases and related surgery · 2021Article
- Do patients benefit from platelet-rich plasma?Joint diseases and related surgery · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to investigate the effects of hyperbaric oxygen (HBO) therapy and platelet-rich plasma (PRP) on the regeneration of osteochondral defects of the rats, and the synergistic effect of this combined treatment. MATERIALS AND
methodsThis randomized, controlled, and interventional animal study was conducted between May 2014 and August 2014 Osteochondral regeneration was evaluated in four treatment groups (control, PRP, HBO, and HBO+PRP groups) at the 30th day after iatrogenic injury. Thirty-two female Wistar albino rats (weighing 248-305 g) underwent arthrotomy and osteochondral surgery on left knees. The regenerations of defects were then examined histologically by the modified version of O'Driscoll score.
resultsGroups that were treated with either HBO or PRP alone regenerated significantly better than the control group (p=0.01), while no significant difference was found between the HBO- and PRP-treated groups (p>0.05). The defects in group 4 (treated with both HBO and PRP) regenerated significantly better than the control group, the HBO-treated group alone, and the PRP-treated group alone (p=0.01).
conclusionThe results of this study showed a synergistic effect of HBO and PRP on knee cartilage regeneration. However, the possible underlying mechanisms should be the subject of future researches. The aggregation and activation of growth factors released from platelets whose activation is increased in the hyperbaric environment may explain this effect. This may result in a better regeneration than the effect of PRP or HBO alone.
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