Evidence map›Paper›PMID 32584506›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.

Ulrike Lisewski, Clemens Köhncke, Leonhard Schleussner, Bettina Purfürst, Soo Min Lee, Angele De Silva, Rían W Manville, Geoffrey W Abbott, Torsten K Roepke

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ulrike LisewskiExperimental and Clinical Research Center, Berlin, Germany.
Clemens KöhnckeExperimental and Clinical Research Center, Berlin, Germany.
Leonhard SchleussnerExperimental and Clinical Research Center, Berlin, Germany.
Bettina PurfürstElectron Microscopy Core Facility, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Soo Min LeeBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Angele De SilvaBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Rían W ManvilleBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Geoffrey W AbbottBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Torsten K RoepkeExperimental and Clinical Research Center, Berlin, Germany.
University of California, Irvine · USCharité - Universitätsmedizin Berlin · DEMax Delbrück Center · DE

Funding

THYROID SODIUM I/ SYMPORTERR01DK041544 · NIDDK · YESHIVA UNIVERSITY · PI ABBOTT, GEOFFREY W, CARRASCO, NANCY · 1989 to 2017
$5.6M
Ion Channel Transporter InteractionsR35GM130377 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Geoffrey W Abbott · 2019 to 2026
$4.0M
Ion channel-transporter interactionsR01GM115189 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ABBOTT, GEOFFREY W · 2015 to 2018
$1.1M
NIDDK NIH HHS R01 DK041544NIGMS NIH HHS R01 GM115189NIGMS NIH HHS R35 GM130377
6 · The paper itself

Abstract

Heart failure (HF) is an increasing global health crisis, affecting 40 million people and causing 50% mortality within 5 years of diagnosis. A fuller understanding of the genetic and environmental factors underlying HF, and novel therapeutic approaches to address it, are urgently warranted. Here, we discovered that cardiac-specific germline deletion in mice of potassium channel β subunit-encoding Kcne2 (Kcne2

Indexed as

AchlorhydriaAnimalsBacteroidesCardiomyopathy, DilatedFemaleGastric AcidGastrointestinal MicrobiomeGene DeletionHeartHeart FailureMaleMiceMice, Inbred C57BLMice, KnockoutPotassium Channels, Voltage-GatedRisk FactorsKcne2 protein, mousePotassium Channels, Voltage-Gateddilated cardiomyopathyheart failureKCNEmicrobiomepotassium channel

Identifiers

PMID32584506
PMCPMC8638375
OpenAlexW3037205316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.