Evidence map›Paper›PMID 32584487›Full record

ArticleJournal of medical virology2021

Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience.

Mariawy Riollano-Cruz, Esra Akkoyun, Eudys Briceno-Brito, Shanna Kowalsky, James Reed, Roberto Posada, Emilia Mia Sordillo, Michael Tosi, Rebecca Trachtman, Alberto Paniz-Mondolfi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 12 pooled it
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 12 syntheses or guidelines pooled it, 174 citations in OpenAlex.

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  8. Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mariawy Riollano-CruzDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Esra AkkoyunDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Eudys Briceno-BritoDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Shanna KowalskyDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
James ReedDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Roberto PosadaDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Emilia Mia SordilloDepartment of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Michael TosiDepartment of Pediatric Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
Rebecca TrachtmanDepartment of Pediatric Rheumatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Alberto Paniz-MondolfiDepartment of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-1259-1736
Icahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.

Indexed as

AdolescentChildChild, PreschoolCOVID-19CytokinesFemaleHumansMaleNew York CityRetrospective StudiesSystemic Inflammatory Response SyndromeTertiary Care CentersYoung AdultCytokinesCOVID-19hyperinflammatory syndromeKawasaki diseaseSARS-CoV-2

Identifiers

PMID32584487
PMCPMC7361761
OpenAlexW3037972015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.