Evidence map›Paper›PMID 32584462›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non-Covalent Chemistries.

Giulia Morgese, Bas F M de Waal, Silvia Varela-Aramburu, Anja R A Palmans, Lorenzo Albertazzi, E W Meijer

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
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  8. Visualizing the Heterogeneity in Homogeneous Supramolecular Polymers.Journal of the American Chemical Society · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Supramolecular biomaterials for bio-imaging and imaging-guided therapy.European journal of nuclear medicine and molecular imaging · 2022
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Giulia MorgeseLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600MB, Eindhoven, The Netherlands.
Bas F M de WaalLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600MB, Eindhoven, The Netherlands.
Silvia Varela-AramburuLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600MB, Eindhoven, The Netherlands.
Anja R A PalmansLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600MB, Eindhoven, The Netherlands.
Lorenzo AlbertazziDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600MB, Eindhoven, The Netherlands.
E W MeijerLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5600MB, Eindhoven, The Netherlands.ORCID 0000-0003-4126-7492
Eindhoven University of Technology · NLInstitute for Bioengineering of Catalonia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding cell/material interactions is essential to design functional cell-responsive materials. While the scientific literature abounds with formulations of biomimetic materials, only a fraction of them focused on mechanisms of the molecular interactions between cells and material. To provide new knowledge on the strategies for materials/cell recognition and binding, supramolecular benzene-1,3,5-tricarboxamide copolymers bearing benzoxaborole moieties are anchored on the surface of human erythrocytes via benzoxaborole/sialic-acid binding. This interaction based on both dynamic covalent and non-covalent chemistries is visualized in real time by means of total internal reflection fluorescence microscopy. Exploiting this imaging method, we observe that the functional copolymers specifically interact with the cell surface. An optimal fiber affinity towards the cells as a function of benzoxaborole concentration demonstrates the crucial role of multivalency in these cell/material interactions.

Indexed as

BenzamidesBiomimetic MaterialsBoronic AcidsErythrocytesHumansMacromolecular SubstancesMicroscopy, FluorescenceMolecular StructureParticle SizePolymersSurface PropertiesBenzamidesbenzene-1,3,5-tricarboxamideBoronic AcidsMacromolecular SubstancesPolymersboronic acidcell/material interactionsmultivalencyred blood cellssupramolecular polymers

Identifiers

PMID32584462
PMCPMC7540258
OpenAlexW3037411041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.