ArticleAdvances in nutrition (Bethesda, Md.)2020
Can Children Catch up from the Consequences of Undernourishment? Evidence from Child Linear Growth, Developmental Epigenetics, and Brain and Neurocognitive Development.
Article in Advances in nutrition (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
- Assessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial.Epigenetics · 2023Trial
- Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam.The Journal of nutrition · 2023Trial
- Home environment and nutritional status mitigate the wealth gap in child development: a longitudinal study in Vietnam.BMC public health · 2023Trial
- Longitudinal assessments of child growth: A six-year follow-up of a cluster-randomized maternal education trial.Clinical nutrition (Edinburgh, Scotland) · 2021Trial
- Stunting Reversal versus Regression to the Mean in Epidemiological Studies of Child Linear Growth in Low- and Middle-Income Countries.Advances in nutrition (Bethesda, Md.) · 2026Review
- Nutraceutical Interventions in Stunting: Advances, Challenges, and Prospects.Food science & nutrition · 2026Review
- Development and Validation of Non-Invasive Machine-Learning Screening Models for Pediatric Malnutrition in Hospitalized Children: A Single-Center Study.Children (Basel, Switzerland) · 2026Article
- Association between size at birth, rapid weight gain in infancy, and overweight status among Palestinian refugees under 5 years old: a retrospective cohort study.The American journal of clinical nutrition · 2026Article
- Risk Factors for Rapid Growth in Undernourished Children: Analysis of Indonesian Family Life Survey.Acta medica Philippina · 2026Article
- Predictors of impaired growth during the first year of life: findings from a longitudinal cohort study in Pakistan.Frontiers in nutrition · 2026Article
- Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit.Molecular psychiatry · 2025Article
- Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting.Epigenetics · 2024Article
- The next 1000 days: building on early investments for the health and development of young children.Lancet (London, England) · 2024Review
- Examining the burden and relationship between stunting and wasting among Timor-Leste under five rural children.PloS one · 2024Article
- Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial.Frontiers in nutrition · 2024Article
- Identifying and understanding barriers to optimal complementary feeding in Kenya.Maternal & child nutrition · 2024Article
- Machine Learning Algorithms for Predicting Stunting among Under-Five Children in Papua New Guinea.Children (Basel, Switzerland) · 2023Article
- The rise and fall of SES gradients in heights around the world.Journal of health economics · 2023Article
- Enhancing Capacity for Food and Nutrient Intake Assessment in Population Sciences Research.Annual review of public health · 2023Review
- Study of the importance of protein needs for catch-up growth in Indonesian stunted children: a narrative review.SAGE open medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recovery from nutritionally induced height deficits continues to garner attention. The current literature on catch-up growth, however, has 2 important limitations: wide-ranging definitions of catch-up growth are used, and it remains unclear whether children can recover from the broader consequences of undernutrition. We addressed these shortcomings by reviewing the literature on the criteria for catch-up in linear growth and on the potential to recover from undernutrition early in life in 3 domains: linear growth, developmental epigenetics, and child brain and neurocognitive development. Four criteria must be met to demonstrate catch-up growth in height: after a period in which a growth-inhibiting condition (criterion 1) causes a reduction in linear growth velocity (criterion 2), alleviation of the inhibiting condition (criterion 3) leads to higher-than-normal velocity (criterion 4). Accordingly, studies that are observational, do not use absolute height, or have no alleviation of an inhibiting condition cannot be used to establish catch-up growth. Adoption and foster care, which provide dramatic improvements in children's living conditions not typically attained in nutrition interventions, led to some (but incomplete) recovery in linear growth and brain and neurocognitive development. Maternal nutrition around the time of conception was shown to have long-term (potentially permanent) effects on DNA methylation in the offspring. Undernourishment early in life may thus have profound irreversible effects. Scientific, program, and policy efforts should focus on preventing maternal and child undernutrition rather than on correcting its consequences or attempting to prove they can be corrected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.