Evidence map›Paper›PMID 32584314›Full record

ArticleEndoscopic ultrasound

Diagnostic efficacy of white core cutoff lengths obtained by EUS-guided fine-needle biopsy using a novel 22G franseen biopsy needle and sample isolation processing by stereomicroscopy for subepithelial lesions.

Kosuke Okuwaki, Hironori Masutani, Mitsuhiro Kida, Hiroshi Yamauchi, Tomohisa Iwai, Eiji Miyata, Rikiya Hasegawa, Toru Kaneko, Hiroshi Imaizumi, Masafumi Watanabe and 5 more

Open access · greenAbstract read
In one paragraph

Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  3. Approach to Gastric Subepithelial Lesions: From Differential Diagnosis to Histologic Confirmation.The Korean journal of helicobacter and upper gastrointestinal research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Kosuke OkuwakiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hironori MasutaniDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Mitsuhiro KidaDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hiroshi YamauchiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Tomohisa IwaiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Eiji MiyataDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Rikiya HasegawaDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Toru KanekoDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hiroshi ImaizumiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Masafumi WatanabeDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Takahiro KurosuDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Masayoshi TadeharaDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Kai AdachiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Akihiro TamakiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Wasaburo KoizumiDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Kitasato University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to estimate the cutoff length for stereomicroscopically visible white core (SVWC) required for the pathological diagnosis of subepithelial lesions (SELs) from samples obtained using a novel 22-G Franseen biopsy needle and determine the sensitivity using the SVWC cutoff length. PATIENTS AND

methodsThirty patients with SELs requiring pathological diagnoses were included. EUS-guided fine-needle biopsies (EUS-FNBs) were performed using a novel 22G Franseen biopsy needle. SVWC cutoff lengths were measured using sample isolation processing by stereomicroscopy (SIPS). The utility of the calculated SVWC cutoff lengths was measured.

resultsThe procedural success and SVWC sampling rates were both 100%. The median SVWC length was 14.5 mm. Pathological examinations identified 16 patients with gastrointestinal stromal tumors, 7 with schwannomas, 6 with leiomyomas, and 1 with an ectopic pancreas. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for diagnosing malignancy using EUS-FNB were all 100%. The final diagnostic accuracy was 100%. Regarding the final diagnosis, based on the receiver operating characteristic curves calculated using the SVWC length, the area under the curve was 0.958 (95% confidence interval: 0.897-1.020, P < 0.001) and the cutoff length was 4 mm. The sensitivity of the new SVWC cutoff length was 98.7%.

conclusionsDiagnostic results of EUS-FNBs using a novel 22-G Franseen biopsy needle were significantly better with SVWC cutoff lengths ≥4 mm. Performing the SIPS procedure with a cutoff value of 4 mm as an index may be especially useful for successful pathological diagnosis of SELs at institutions where rapid on-site evaluation cannot be performed.

Indexed as

EUSfine-needle biopsyhistopathologysample isolation processing by stereomicroscopysubepithelial lesion

Identifiers

PMID32584314
PMCPMC7430899
OpenAlexW3037287755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.