ArticleProceedings of the National Academy of Sciences of the United States of America1988
Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 301 citations in OpenAlex.
- Regulators and Conductors of Immunity: Natural Immune System in Health and Autoimmunity.International journal of molecular sciences · 2025Review
- Animal models of neuropsychiatric systemic lupus erythematosus: deciphering the complexity and guiding therapeutic development.Autoimmunity · 2024Review
- SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus.Scientific reports · 2019Article
- Innate and humoral recognition of the products of cell death: differential antigenicity and immunogenicity in lupus.Clinical and experimental immunology · 2017Article
- The Significance of a Common Idiotype (1F7) on Antibodies against Human Immune Deficiency Virus Type 1 and Hepatitis C Virus.Frontiers in oncology · 2016Review
- Standardization of autoantibody testing: a paradigm for serology in rheumatic diseases.Nature reviews. Rheumatology · 2014Review
- 16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus.BMC medicine · 2013Article
- Regulatory T-cell-associated cytokines in systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2011Review
- The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases.Cellular and molecular life sciences : CMLS · 2010Review
- A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide.Journal of clinical immunology · 2010Article
- The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models.Immunology · 2009Article
- A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Polyclonal B-cell expansion in the cerebrospinal fluid of patients with pseudotumor cerebri.Journal of clinical immunology · 2004Article
- A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation.Journal of clinical immunology · 2004Article
- Amelioration of lupus manifestations by a peptide based on the complementarity determining region 1 of an autoantibody in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patients.Clinical and experimental immunology · 2004Article
- T cell help is required to induce idiotypic-anti-idiotypic autoantibody network after immunization with complementary epitope 289-308aa of La/SSB autoantigen in non-autoimmune mice.Clinical and experimental immunology · 2004Article
- Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus.The Journal of clinical investigation · 2003Article
- Lupus manifestations in severe combined immunodeficient (SCID) mice and in human/mouse radiation chimeras.Journal of clinical immunology · 2003Article
- Modulation of autoreactive responses of peripheral blood lymphocytes of patients with systemic lupus erythematosus by peptides based on human and murine anti-DNA autoantibodies.Clinical and experimental immunology · 2003Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic lupus erythematosus (SLE) is considered to be the quintessential autoimmune disease. It has not been possible to induce SLE in animal models by DNA immunization or by challenge with anti-DNA antibodies. We herewith report a murine model of SLE-like disease induced by immunization of C3H.SW female mice with a common human monoclonal anti-DNA idiotype (16/6 idiotype). Following a booster injection with the 16/6 idiotype, high levels of murine anti-16/6 and anti-anti-16/6 antibodies (associated with anti-DNA activity) were detected in the sera of the immunized mice. Elevated titers of autoantibodies reacting with DNA, poly(I), poly(dT), ribonucleoprotein, autoantigens [Sm, SS-A (Ro), and SS-B (La)], and cardiolipin were noted. The serological findings were associated with increased erythrocyte sedimentation rate, leukopenia, proteinuria, immune complex deposition in the glomerular mesangium, and sclerosis of the glomeruli. The immune complexes in the kidneys were shown to contain the 16/6 idiotype. This experimental SLE-like model may be used to elucidate the mechanisms underlying SLE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.