Trial reportAmerican journal of respiratory and critical care medicine2020
The Effect of Inhaled Corticosteroid Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study. A Randomized, Double-Blind, Multicenter Clinical Trial.
Open access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Inhaled corticosteroids with combination inhaled long-acting beta2-agonists and long-acting muscarinic antagonists for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2023Pooled it
- Triple versus LAMA/LABA combination therapy for patients with COPD: a systematic review and meta-analysis.Respiratory research · 2021Pooled it
- Cardiac Overload and Heart Failure Risk by NT-proBNP Levels in Older Adults with COPD Eligible for Single-Inhaler Triple Therapy: A Multicenter Longitudinal Study.Journal of clinical medicine · 2025Article
- Emulating randomized trials by observational database studies: the RCT-DUPLICATE initiative in COPD and asthma.American journal of epidemiology · 2025Article
- Triple Therapy De-Escalation and Withdrawal of Inhaled Corticosteroids to Dual Bronchodilator Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Idiopathic pulmonary fibrosis is more strongly associated with coronary artery disease than chronic obstructive pulmonary disease.Respiratory medicine · 2023Article
- Triple therapy in COPD: understanding the data.ERJ open research · 2023Article
- Single-Inhaler Triple versus Dual Bronchodilator Therapy in COPD: Real-World Comparative Effectiveness and Safety.International journal of chronic obstructive pulmonary disease · 2022Article
- Update in Chronic Obstructive Pulmonary Disease 2020.American journal of respiratory and critical care medicine · 2021Article
- ACO (Asthma-COPD Overlap) Is Independent from COPD: The Case in Favour.Diagnostics (Basel, Switzerland) · 2021Review
- Lack of Bacterial Colonization Measure in Randomized Controlled Trial on Inhaled Corticosteroids Effect in Patients with Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2021Article
- The Role of Eosinophils during the Withdrawal of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2021Article
- Reply to Wang and Lai: The Role of Eosinophils during the Withdrawal of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2021Article
- One More Time: The Impact of Inhaled Corticosteroid Withdrawal on IMPACT.American journal of respiratory and critical care medicine · 2020Article
- Inhaled Corticosteroid Withdrawal in Chronic Obstructive Pulmonary Disease: Can IMPACT Help?American journal of respiratory and critical care medicine · 2020Article
- Angels Dancing on the Tip of a Needle: Interpreting Clinical Trials in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2020Article
- Benefit/Risk Profile of Single-Inhaler Triple Therapy in COPD.International journal of chronic obstructive pulmonary diseaseReview
- Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.Tzu chi medical journalArticle
Corrections and comments
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Authors and funding
14 authors at 12 institutions in 3 countries.
MeiLan K HanDivision of Pulmonary and Critical Care, University of Michigan, Ann Arbor, Michigan.
Gerard J CrinerPulmonary and Critical Care Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Mark T DransfieldDivision of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama.
David M G HalpinUniversity of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.
C Elaine JonesDevelopment, Research and Development, and.
Sally KilbrideClinical Sciences, GlaxoSmithKline, Collegeville, Pennsylvania.
Peter LangeBiostatistics, GlaxoSmithKline, Stockley Park West, Uxbridge, Middlesex, United Kingdom.
Sally LettisClinical Sciences, GlaxoSmithKline, Collegeville, Pennsylvania.
David A LipsonMedical Department, Pulmonary Section, Herlev-Gentofte Hospital, Herlev, Denmark.
David A LomasUCL Respiratory, University College London, London, United Kingdom.
Neil MartinGlobal Medical Affairs, GlaxoSmithKline, Brentford, Middlesex, United Kingdom.
Robert A WiseDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dave SinghCentre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester University NHS Foundation Trust, Manchester, United Kingdom; and.
Fernando J MartinezNew York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York.
GlaxoSmithKline (United States) · USGentofte Hospital · DKJohns Hopkins University · USManchester Academic Health Science Centre · GBNewYork–Presbyterian Hospital · USTemple University · USUniversity College London · GBUniversity of Alabama at Birmingham · USUniversity of Copenhagen · DKUniversity of Exeter · GBUniversity of Leicester · GBUniversity of Michigan · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Administration, InhalationAgedBenzyl AlcoholsBronchodilator AgentsChlorobenzenesDouble-Blind MethodFemaleFluticasoneHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveQuinuclidinesSubstance Withdrawal SyndromeBenzyl AlcoholsBronchodilator AgentsChlorobenzenesFluticasoneGSK573719Quinuclidinesvilanterolchronic obstructive pulmonary diseasestep downtriple therapy
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.