Evidence map›Paper›PMID 32584141›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR.

Susan E Birket, Joy M Davis, Courtney M Fernandez-Petty, Alexander G Henderson, Ashley M Oden, LiPing Tang, Hui Wen, Jeong Hong, Lianwu Fu, Andre Chambers and 5 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Evaluating the effects of ivacaftor exposure onJAC-antimicrobial resistance · 2024
    Article
  8. Article
  9. Article
  10. Normalization of Muc5b ameliorates airway mucus plugging during persistentAmerican journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Animals in Respiratory Research.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
  18. Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Susan E BirketDepartment of Medicine.
Joy M DavisDepartment of Medicine.
Courtney M Fernandez-PettyDepartment of Medicine.
Alexander G HendersonDepartment of Medicine.
Ashley M OdenDepartment of Medicine.
LiPing TangDepartment of Medicine.
Hui WenCystic Fibrosis Research Center, and.
Jeong HongDepartment of Pediatrics, Emory University, Atlanta, Georgia.
Lianwu FuCystic Fibrosis Research Center, and.
Andre ChambersHorizon Discovery Group PLC, St. Louis, Missouri; and.
Alvin FieldsHorizon Discovery Group PLC, St. Louis, Missouri; and.
Gojun ZhaoHorizon Discovery Group PLC, St. Louis, Missouri; and.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Eric J SorscherCell, Developmental, and Integrated Biology, University of Alabama at Birmingham, Birmingham, Alabama.
Steven M RoweDepartment of Medicine.
Horizon Discovery Group (United States) · USUniversity of Alabama at Birmingham · USCystic Fibrosis Research Foundation · ITEmory University · USMassachusetts General Hospital · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI George Martin Solomon · 2007 to 2026
$23.0M
Translational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3M
The Role of Airway Mucus in Infection and InflammationR01HL153079 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2021 to 2025
$2.2M
The Mechanisms Underlying Abnormal Mucus and its Clearance in the Cystic Fibrosis RatK08HL131867 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2017 to 2021
$637k
NHLBI NIH HHS K08 HL131867NHLBI NIH HHS L40 HL129387NHLBI NIH HHS R01 HL153079NHLBI NIH HHS R35 HL135816NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminophenolsAnimalsChloride Channel AgonistsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorHumansModels, AnimalMucusQuinolonesRatsAminophenolsChloride Channel AgonistsCystic Fibrosis Transmembrane Conductance RegulatorivacaftorQuinolonescystic fibrosisG551Divacaftormucusrat model

Identifiers

PMID32584141
PMCPMC7605185
OpenAlexW3037175551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.